Skip to Main Content
Frequently Asked Questions
Submit an ETD
Global Search Box
Need Help?
Keyword Search
Participating Institutions
Advanced Search
School Logo
Files
File List
thesis Zhaoqi Zhang.pdf (1.57 MB)
ETD Abstract Container
Abstract Header
Stability Studies of MOMIPP, an Inducer of Methuosis
Author Info
Zhang, Zhaoqi
Permalink:
http://rave.ohiolink.edu/etdc/view?acc_num=mco1418402908
Abstract Details
Year and Degree
2014, Master of Science (MS), University of Toledo, Medicinal Chemistry.
Abstract
Recently, “methuosis” has been identified and labeled as a novel type of cell death. One of the most potent inducers of methuosis is 3-(5-methoxy-2-methyl-1H-indol-3-yl)-1-(4-pyridinyl)-2-propen-1-one which is abbreviated as “MOMIPP”. MOMIPP is being developed as a treatment for glioblastoma. As part of MOMIPP’s development, we are evaluating its stability under several storage and exposure conditions. These include storage in DMSO or chloroform:methanol (2:1) from -80 °C to room temperature for up to 6 months. Likewise, the effects of UV/visible light exposure and storage under high levels of oxygen were assessed. We also evaluated the possibility that MOMIPP might be subject to change when undergoing several freeze-thaw procedure steps or when placed on an HPLC autosampler for prolonged periods of time. Results indicate MOMIPP is stable in DMSO at most temperatures but evaporation is a problem in chloroform-methanol (2:1) except at the lowest temperature. Continuous UV light exposure appears to cause a small amount of breakdown, while visible light does not yield any significant change. Freeze-thawing should be acceptable for up to 5 cycles and placement of samples on an HPLC autosampler should not extend past 2 days. Based on these results, optimal storage and handling conditions have been establish for MOMIPP solutions that will be used during its potential development as a new drug candidate.
Committee
Paul Erhardt (Committee Chair)
Jeffery Sarver (Committee Member)
Amanda Bryant-Friedrich (Committee Member)
Pages
78 p.
Subject Headings
Pharmaceuticals
Keywords
MOMIPP, HPLC, LC-MS, Stability tests
Recommended Citations
Refworks
EndNote
RIS
Mendeley
Citations
Zhang, Z. (2014).
Stability Studies of MOMIPP, an Inducer of Methuosis
[Master's thesis, University of Toledo]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=mco1418402908
APA Style (7th edition)
Zhang, Zhaoqi.
Stability Studies of MOMIPP, an Inducer of Methuosis.
2014. University of Toledo, Master's thesis.
OhioLINK Electronic Theses and Dissertations Center
, http://rave.ohiolink.edu/etdc/view?acc_num=mco1418402908.
MLA Style (8th edition)
Zhang, Zhaoqi. "Stability Studies of MOMIPP, an Inducer of Methuosis." Master's thesis, University of Toledo, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=mco1418402908
Chicago Manual of Style (17th edition)
Abstract Footer
Document number:
mco1418402908
Download Count:
562
Copyright Info
© 2014, all rights reserved.
This open access ETD is published by University of Toledo Health Science Campus and OhioLINK.