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Stability Studies of MOMIPP, an Inducer of Methuosis

Zhang, Zhaoqi

Abstract Details

2014, Master of Science (MS), University of Toledo, Medicinal Chemistry.
Recently, “methuosis” has been identified and labeled as a novel type of cell death. One of the most potent inducers of methuosis is 3-(5-methoxy-2-methyl-1H-indol-3-yl)-1-(4-pyridinyl)-2-propen-1-one which is abbreviated as “MOMIPP”. MOMIPP is being developed as a treatment for glioblastoma. As part of MOMIPP’s development, we are evaluating its stability under several storage and exposure conditions. These include storage in DMSO or chloroform:methanol (2:1) from -80 °C to room temperature for up to 6 months. Likewise, the effects of UV/visible light exposure and storage under high levels of oxygen were assessed. We also evaluated the possibility that MOMIPP might be subject to change when undergoing several freeze-thaw procedure steps or when placed on an HPLC autosampler for prolonged periods of time. Results indicate MOMIPP is stable in DMSO at most temperatures but evaporation is a problem in chloroform-methanol (2:1) except at the lowest temperature. Continuous UV light exposure appears to cause a small amount of breakdown, while visible light does not yield any significant change. Freeze-thawing should be acceptable for up to 5 cycles and placement of samples on an HPLC autosampler should not extend past 2 days. Based on these results, optimal storage and handling conditions have been establish for MOMIPP solutions that will be used during its potential development as a new drug candidate.
Paul Erhardt (Committee Chair)
Jeffery Sarver (Committee Member)
Amanda Bryant-Friedrich (Committee Member)
78 p.

Recommended Citations

Citations

  • Zhang, Z. (2014). Stability Studies of MOMIPP, an Inducer of Methuosis [Master's thesis, University of Toledo]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=mco1418402908

    APA Style (7th edition)

  • Zhang, Zhaoqi. Stability Studies of MOMIPP, an Inducer of Methuosis. 2014. University of Toledo, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=mco1418402908.

    MLA Style (8th edition)

  • Zhang, Zhaoqi. "Stability Studies of MOMIPP, an Inducer of Methuosis." Master's thesis, University of Toledo, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=mco1418402908

    Chicago Manual of Style (17th edition)