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Evaluation of the Percutaneous Absorption of Chlorpromazine Hydrochloride from PLO Gels Across Porcine Ear and Human Abdominal Skin

Alsaab, Hashem O
http://rave.ohiolink.edu/etdc/view?acc_num=mco1435670713

Abstract Details

2015, Master of Science (MS), University of Toledo, College of Pharmacy.
The overall objective of this work is to determine the percutaneous absorption of chlorpromazine hydrochloride from PLO gels and verify the suitability of a topically applied chlorpromazine PLO gel for use in hospice patients to relieve symptoms such as vomiting and nausea at the end stages of life. The aims of the present study were to (a) prepare and characterize pluronic lecithin organogels (PLO gels) of chlorpromazine hydrochloride using isopropyl palmitate or ricinoleic acid as the oil phase, (b) assess the in vitro percutaneous absorption of chlorpromazine hydrochloride through porcine ear and human abdominal skin using isopropyl palmitate and ricinoleic acid PLO gels, and (c) assess the theoretical plasma concentrations of chlorpromazine from flux values. PLO gels of chlorpromazine hydrochloride were successfully prepared using isopropyl palmitate or ricinoleic acid as the oil phase and characterized for pH, morphology, stability, viscosity, thermal analysis using differential scanning calorimetry (DSC), in vitro drug release and stability. In vitro permeability studies were performed across pig ear and human abdominal skin using isopropyl palmitate PLO gel and compared with the ricinoleic acid PLO gel. The pH and viscosity of both PLO gels prepared with isopropyl palmitate and ricinoleic acid were comparable. The thixotropic property of ricinoleic acid PLO gel was found to be better than the isopropyl palmitate PLO gel. Both formulations were found to be stable at 25ºC, 35ºC, and 40ºC for up to 60 days. The permeation of chlorpromazine hydrochloride was higher from ricinoleic acid PLO gel than isopropyl palmitate PLO gel and pure drug solution. Theoretical steady state plasma concentrations (Css) of chlorpromazine from pure drug solution, isopropyl palmitate PLO gel and ricinoleic acid PLO gel were found to be 1.05, 1.20, and 1.50 ng/ml. PLO gels only marginally increased the flux and theoretical Css of chlorpromazine. However, theoretical Css values for chlorpromazine were much below the required therapeutic concentration for antiemetic activity in hospice patients. From this study it is clearly evident that PLO gels fail to deliver the required systemic levels of chlorpromazine following topical application. To achieve better chlorpromazine hydrochloride skin permeation and thus higher concentrations of chlorpromazine in plasma, following topical application on the skin, ef¿cient permeation enhancers should be used.
Sai HS Boddu (Advisor)
KENNETH S. ALEXANDER (Committee Member)
YOUSSEF SARI (Committee Member)
101 p.
Pharmaceuticals; Pharmacy Sciences
Pluronic F127, lecithin, ricinoleic acid, pluronic lecithin organogel

Recommended Citations

Citations

  • Alsaab, H. O. (2015). Evaluation of the Percutaneous Absorption of Chlorpromazine Hydrochloride from PLO Gels Across Porcine Ear and Human Abdominal Skin [Master's thesis, University of Toledo]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=mco1435670713

    APA Style (7th edition)

  • Alsaab, Hashem. Evaluation of the Percutaneous Absorption of Chlorpromazine Hydrochloride from PLO Gels Across Porcine Ear and Human Abdominal Skin. 2015. University of Toledo, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=mco1435670713.

    MLA Style (8th edition)

  • Alsaab, Hashem. "Evaluation of the Percutaneous Absorption of Chlorpromazine Hydrochloride from PLO Gels Across Porcine Ear and Human Abdominal Skin." Master's thesis, University of Toledo, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=mco1435670713

    Chicago Manual of Style (17th edition)

mco1435670713
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© 2015, some rights reserved.Creative Commons License Evaluation of the Percutaneous Absorption of Chlorpromazine Hydrochloride from PLO Gels Across Porcine Ear and Human Abdominal Skin by Hashem O Alsaab is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported License. Based on a work at etd.ohiolink.edu.
This open access ETD is published by University of Toledo Health Science Campus and OhioLINK.