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Md zubayer Hossain Saad _ Thesis.pdf (815.54 KB)

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Mechanosensory Role of Vascular Endothelial Primary Cilia in the Development of Hypertension in Polycystic Kidney Disease

Hossain Saad, Md Zubayer
http://orcid.org/0000-0001-9324-0481
http://rave.ohiolink.edu/etdc/view?acc_num=mco1461947903

Abstract Details

2016, Master of Science in Pharmaceutical Science (MSP), University of Toledo, Pharmaceutical Sciences (Pharmacology/Toxicology).
Autosomal Dominant Polycystic Kidney Disease (ADPKD) is the most common life-threatening hereditary genetic disease. Early cardiovascular complications, including hypertension, have been witnessed in the majority of the ADPKD patients, and have been attributed as the primary cause of mortality. PKD originates from defective primary cilia which have a mutation in either the Pkd1 or Pkd2 gene. These two genes encode for polycystin-1 and polycystin-2 respectively, and lack of their ciliary localization has already been established as an essential element in PKD pathophysiology. Endothelial primary cilia in the inner surface of blood vessels sense blood flow and convert it into intracellular biochemical signals. Vascular endothelial cilia have been demonstrated to have a polycystin-1 and polycystin-2 mediated mechanosensory mechanism. Intracellular nitric oxide (NO) is one of the most important regulators of blood pressure; in-vitro studies showed that vascular endothelial ciliary polycystin-1 and polycystin-2 controls NO biosynthesis by a calcium signaling pathway. In this study, we focused on the role of vascular endothelial cilia in the initiation and the development of hypertension in PKD. In addition to studying vascular phenotypes of the mutant Pkd1 animal model, we also extended our investigation in the analysis of the mechanism of hypertension in PKD by looking into the transient receptor potential channels, which have been evidenced for mechanosensory activity in vascular endothelium.
Wissam AbouAlaiwi (Committee Chair)
Ezdihar Hassoun (Committee Member)
Williams Frederick (Committee Member)
57 p.
Cellular Biology; Molecular Biology; Pharmacology
cilia, Polycystic kidney disease, hypertension, endothelium

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Citations

  • Hossain Saad, M. Z. (2016). Mechanosensory Role of Vascular Endothelial Primary Cilia in the Development of Hypertension in Polycystic Kidney Disease [Master's thesis, University of Toledo]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=mco1461947903

    APA Style (7th edition)

  • Hossain Saad, Md Zubayer. Mechanosensory Role of Vascular Endothelial Primary Cilia in the Development of Hypertension in Polycystic Kidney Disease. 2016. University of Toledo, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=mco1461947903.

    MLA Style (8th edition)

  • Hossain Saad, Md Zubayer. "Mechanosensory Role of Vascular Endothelial Primary Cilia in the Development of Hypertension in Polycystic Kidney Disease." Master's thesis, University of Toledo, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=mco1461947903

    Chicago Manual of Style (17th edition)

mco1461947903
423
© 2016, all rights reserved.
This open access ETD is published by University of Toledo Health Science Campus and OhioLINK.