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Tibia Morphology & Bone Marrow Adipose Tissue Phenotype is Controlled by Sex Steroids in C57BL/6 Mice

Sherman, Shermel B

Abstract Details

2016, Master of Science in Biomedical Sciences (MSBS), University of Toledo, Biomedical Sciences (Orthopaedic Sciences).
Bone marrow adipose tissue (BMAT) is an endocrine organ and heterogenic adipose depot that is located throughout the body in the marrow of bones. BMAT has the potential to modulate bone microenvironment. Recent studies have found that it is region-specific and species specific under various metabolic pathophysiological conditions such as aging, caloric restriction, diabetes, and sex steroid deficiency. Previously, our lab concluded that BMAT has phenotypic characteristics of white adipose tissue (WAT), brown adipose tissue (BAT), and brown-like or beige adipose tissue. This project investigated whether sex steroids control the bone morphology and phenotype of bone marrow adipose tissue in male and female animals. Results indicate that there are significant differences in bone mass and fat deposition of the tibia of adult male and female mice. However, sexual dimorphism in the expression of those adipose tissue markers in the BMAT was not observed in the qRT-PCR analysis of the proximal tibia of OVX and ORX animals.
BEATA LECKA-CZERNIK (Advisor)
MARTIN SKIE (Committee Chair)
A CHAMPA JAYASURIYA (Committee Member)
EDWIN SANCHEZ (Committee Member)
JENNIFER HILL (Committee Member)
54 p.

Recommended Citations

Citations

  • Sherman, S. B. (2016). Tibia Morphology & Bone Marrow Adipose Tissue Phenotype is Controlled by Sex Steroids in C57BL/6 Mice [Master's thesis, University of Toledo]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=mco1461972446

    APA Style (7th edition)

  • Sherman, Shermel. Tibia Morphology & Bone Marrow Adipose Tissue Phenotype is Controlled by Sex Steroids in C57BL/6 Mice. 2016. University of Toledo, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=mco1461972446.

    MLA Style (8th edition)

  • Sherman, Shermel. "Tibia Morphology & Bone Marrow Adipose Tissue Phenotype is Controlled by Sex Steroids in C57BL/6 Mice." Master's thesis, University of Toledo, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=mco1461972446

    Chicago Manual of Style (17th edition)