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Effective Topical Delivery of Ibuprofen through the Skin

Porter, Audree Elizabeth

Abstract Details

2016, Master of Science in Pharmaceutical Science (MSP), University of Toledo, Pharmaceutical Sciences (Industrial Pharmacy).
The ability to effectively deliver non-steroidal anti-inflammatory drugs (NSAIDs) topically and transdermally offers an increased localization of the drug to the site of pain and inflammation, while simultaneously reducing systemic absorption. This ultimately results in more effective treatment for localized pain and inflammation, while reducing the undesired side effects associated with NSAIDs. In this work, effective topical delivery was studied, specifically to compare and contrast the effects of three separate penetration enhancers utilizing in vitro Franz cell testing methods. Ten formulations, using three different penetration enhancers (Kollicream OA, Kollicream IPM and Kollicream 3C) and two different active pharmaceutical ingredients (ibuprofen and sodium ibuprofen), were tested and results are given in this report. Ultimately, the penetration enhancers were found to impede delivery of active pharmaceutical drugs into the epidermis of the skin over an 8-hour period as compared to a standard blank cream run concurrently. Kollicream 3C was shown to have the best release profile over the initial first hour of the study, mimicking the initial application of the pharmaceutical product. Kollicream OA was shown to have the best release profile over the entire 8-hour period.
Kenneth Alexander, Ph.D (Committee Chair)
Gabriella Baki, Ph.D. (Committee Member)
Marcia McInerney, Ph.D. (Committee Member)

Recommended Citations

Citations

  • Porter, A. E. (2016). Effective Topical Delivery of Ibuprofen through the Skin [Master's thesis, University of Toledo]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=mco1470324493

    APA Style (7th edition)

  • Porter, Audree. Effective Topical Delivery of Ibuprofen through the Skin. 2016. University of Toledo, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=mco1470324493.

    MLA Style (8th edition)

  • Porter, Audree. "Effective Topical Delivery of Ibuprofen through the Skin." Master's thesis, University of Toledo, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=mco1470324493

    Chicago Manual of Style (17th edition)