Skip to Main Content
 

Global Search Box

 
 
 

ETD Abstract Container

Abstract Header

Cognitive Impairments after Hemorrhagic Brain Injury: Therapeutic Potential of Cofilin Inhibition

Ali, Mohammad
http://rave.ohiolink.edu/etdc/view?acc_num=mco1628360273767787

Abstract Details

2021, Master of Science in Medicinal Chemistry (MSP), University of Toledo, Medicinal Chemistry.
Intracerebral hemorrhage (ICH) is a type of stroke that caused by a rupture of small arteries and the leaking of blood due to hypertensive changes or other vascular abnormalities. There is no effective treatment for ICH and its delayed effects. A small-molecule cofilin inhibitor (CI) was synthesized in our lab as a potential therapeutic agent for the treatment of hemorrhagic brain injury. In this study, we aimed to investigate the delayed effects of ICH and, in particular, neuroinflammation and cognitive dysfunctions. This was performed by using the collagenase mouse model of ICH and cofilin inhibitor as a therapeutic agent. Animals were randomly subdivided into three groups: sham group (needle insertion only), ICH (vehicle) group, and post-treatment groups (ICH and CI). The post-treatment groups were divided into three groups: ICH and CI (25 mg/kg), ICH and CI (50 mg/kg), and ICH and CI (100 mg/kg). Behavioral parameters for assessing functional and cognitive deficits were performed using rotarod, grip strength, T-maze, wire hang, inverted screen, open field, and neurologic deficit scores in all groups after ICH and drug treatment. Hematoma volume was measured as an endpoint to assess the degree of brain injury and protection with the CI treatment. A significant cognitive impairment was observed in the ICH group. CI treatment led to enhanced neurobehavioral performance, including rotarod, grip strength, T-maze, inverted screen, wire hang, and neurological deficits compared to the control. A significant reduction in hematoma volume was observed in 50 mg/kg and 100 mg/kg treatment groups. Our studies show that ICH results in cognitive impairments in addition to hemorrhagic injury, and CI treatment prevented both hemorrhagic injury and cognitive impairments.
Zahoor Shah (Advisor)
Youssef Sari (Committee Member)
Katherine Wall (Committee Member)
Hermann Grafenstein (Committee Member)
Daniyah Almarghalani (Other)
64 p.
Biology; Chemistry; Pharmaceuticals
Intracerebral Hemorrhage; Cofilin; Cognitive Impairment; Peripheral Leukocytes; Hematoma Volume; Neurobehavioral Parameters; Neuroinflammation.

Recommended Citations

Citations

  • Ali, M. (2021). Cognitive Impairments after Hemorrhagic Brain Injury: Therapeutic Potential of Cofilin Inhibition [Master's thesis, University of Toledo]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=mco1628360273767787

    APA Style (7th edition)

  • Ali, Mohammad. Cognitive Impairments after Hemorrhagic Brain Injury: Therapeutic Potential of Cofilin Inhibition. 2021. University of Toledo, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=mco1628360273767787.

    MLA Style (8th edition)

  • Ali, Mohammad. "Cognitive Impairments after Hemorrhagic Brain Injury: Therapeutic Potential of Cofilin Inhibition." Master's thesis, University of Toledo, 2021. http://rave.ohiolink.edu/etdc/view?acc_num=mco1628360273767787

    Chicago Manual of Style (17th edition)

mco1628360273767787
86
© 2021, some rights reserved.Creative Commons License Cognitive Impairments after Hemorrhagic Brain Injury: Therapeutic Potential of Cofilin Inhibition by Mohammad Ali is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported License. Based on a work at etd.ohiolink.edu.
This open access ETD is published by University of Toledo Health Science Campus and OhioLINK.