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NEUROTROPHIN EXPRESSION IN SYMPATHETIC NEURONS: INFLUENCES OF EXOGENOUS NGF AND AFFERENT INPUT

Jones, Elizabeth Ellen
http://rave.ohiolink.edu/etdc/view?acc_num=miami1089903903

Abstract Details

2004, Master of Science, Miami University, Zoology.
The regulatory mechanisms that promote the survival of adult neurons remain unclear. Target-derived proteins called neurotrophins are known to play a role in the survival of sympathetic neurons, but their exact function is unknown. In the present study, expression of the neurotrophins nerve growth factor (NGF) and neurotrophin-3 (NT-3) in adult sympathetic ganglia and their targets was investigated. Using Western blot analysis, multiple precursor forms of both NGF and NT-3 were observed in neurons and blood vessel targets. In addition, using real time RT-PCR, transcripts for both NGF and NT-3 were detected in the ganglia, demonstrating the potential for neurotrophin synthesis in peripheral ganglia. The expression patterns of both NGF and NT-3 were found to be altered by both exogenous NGF and removal of pre-ganglionic input, suggesting the regulatory influences of both NGF and afferent input on neurotrophin expression and ultimately neuronal survival. Overall, this study advanced the understanding of neurotrophin regulation of neuronal survival.
Lori Isaacson (Advisor)
52 p.
Biology, Neuroscience
neuronal survival; neurotrophins; sympathetic; nerve growth factor or NGF; neurotrophin-3 or NT-3

Recommended Citations

Citations

  • Jones, E. E. (2004). NEUROTROPHIN EXPRESSION IN SYMPATHETIC NEURONS: INFLUENCES OF EXOGENOUS NGF AND AFFERENT INPUT [Master's thesis, Miami University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=miami1089903903

    APA Style (7th edition)

  • Jones, Elizabeth. NEUROTROPHIN EXPRESSION IN SYMPATHETIC NEURONS: INFLUENCES OF EXOGENOUS NGF AND AFFERENT INPUT. 2004. Miami University, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=miami1089903903.

    MLA Style (8th edition)

  • Jones, Elizabeth. "NEUROTROPHIN EXPRESSION IN SYMPATHETIC NEURONS: INFLUENCES OF EXOGENOUS NGF AND AFFERENT INPUT." Master's thesis, Miami University, 2004. http://rave.ohiolink.edu/etdc/view?acc_num=miami1089903903

    Chicago Manual of Style (17th edition)

miami1089903903
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© 2004, all rights reserved.
This open access ETD is published by Miami University and OhioLINK.