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Polymeric polyphenols as anti-inflammatory agents

Perkins, Akeysha A.
http://rave.ohiolink.edu/etdc/view?acc_num=miami1182258706

Abstract Details

2007, Master of Science, Miami University, Chemistry and Biochemistry.
Polyphenols are natural antioxidants found in foods such as berries, tea, and wine. Although polyphenols have been studied extensively in chemical systems, less is known about their activity in biological systems. I am especially interested in polymeric polyphenols, which have a high capacity for radical scavenging and may thus be good inhibitors of the inflammatory cascade. To test the hypothesis, a rabbit monocyte cell system was used. A superoxide burst was monitored using cytochrome c reduction or chemiluminescence. TNF-alpha production was assessed with an ELISA. It was found that a typical polymeric polyphenol, pentagalloyl glucose, was both a superoxide scavenger and a stimulator of TNF-alpha production. Studies of other polyphenolics and of polyphenol-protein complexes in the same system will allow development of structure-activity relationships for radical scavenging and cytokine stimulating activities noted for polymeric polyphenols. Identifying polymeric polyphenols that effectively scavenge radicals without stimulating cytokine production is essential to using polyphenols as anti-inflammatory agents.
Ann Hagerman (Advisor)
86 p.
Chemistry, Biochemistry
tannins; inflammation; antioxidants; pentagalloyl glucose

Recommended Citations

Citations

  • Perkins, A. A. (2007). Polymeric polyphenols as anti-inflammatory agents [Master's thesis, Miami University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=miami1182258706

    APA Style (7th edition)

  • Perkins, Akeysha. Polymeric polyphenols as anti-inflammatory agents. 2007. Miami University, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=miami1182258706.

    MLA Style (8th edition)

  • Perkins, Akeysha. "Polymeric polyphenols as anti-inflammatory agents." Master's thesis, Miami University, 2007. http://rave.ohiolink.edu/etdc/view?acc_num=miami1182258706

    Chicago Manual of Style (17th edition)

miami1182258706
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© 2007, all rights reserved.
This open access ETD is published by Miami University and OhioLINK.