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Urea production capacity in the wood frog (Rana sylvatica) varies with season and experimentally induced hyperuremia

Schiller, Tamar M.

Abstract Details

2007, Master of Science, Miami University, Zoology.
Wood frogs (Rana sylvatica) can accumulate substantial amounts of urea during the winter. In this study maximal urea production capacity is examined in wood frogs collected at various times of the year and in response to experimental hyperuremia and dehydration. Activity and expression of carbamoyl phosphate synthetase I (CPSI), the regulatory enzyme of the urea cycle, are used as indicators of urea production capacity in the wood frog. CPSI activity and expression did change seasonally, though it did not increase in winter. Hyperuremia decreased CPSI activity in hydrated frogs but maintained activity in dehydrated frogs. Changes in CPSI activity were not reflected by similar changes in CPSI quantity suggesting CPSI activity in the wood frog is not primarily being regulated through transcription and translation. Maintenance of urea production capacity in hibernating R. sylvatica probably facilitates accumulation of this osmolyte, which has important roles in the winter biology of this species.
Richard Lee (Advisor)
25 p.

Recommended Citations

Citations

  • Schiller, T. M. (2007). Urea production capacity in the wood frog (Rana sylvatica) varies with season and experimentally induced hyperuremia [Master's thesis, Miami University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=miami1196441446

    APA Style (7th edition)

  • Schiller, Tamar. Urea production capacity in the wood frog (Rana sylvatica) varies with season and experimentally induced hyperuremia. 2007. Miami University, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=miami1196441446.

    MLA Style (8th edition)

  • Schiller, Tamar. "Urea production capacity in the wood frog (Rana sylvatica) varies with season and experimentally induced hyperuremia." Master's thesis, Miami University, 2007. http://rave.ohiolink.edu/etdc/view?acc_num=miami1196441446

    Chicago Manual of Style (17th edition)