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The BMP pathway: Its role in retina regeneration

Gutierrez, Christian
http://rave.ohiolink.edu/etdc/view?acc_num=miami1228837408

Abstract Details

2008, Master of Science, Miami University, Zoology.
The embryonic chick eye is an ideal model to study retina regeneration since it has the ability to regenerate via two different modes: via the activation of stem/progenitor cells located in the anterior region of the eye or via the transdifferentiation of the retinal pigmented epithelium. Both modes give rise to a laminated retina with all major retinal cell types present. In this study we analyze the role of the Bone Morphogenetic Protein (BMP) pathway during the process of chick retina regeneration. The BMP pathway has been well documented in being involved in stem cell maintenance, cell differentiation and apoptosis. We demonstrate that activating the BMP pathway is sufficient to induce retina regeneration from stem/progenitor cells. During the early stages of retina regeneration, the BMP pathway promotes Fibroblast Growth Factor (FGF) signaling through the activation of its canonical pathway to promote proliferation, leading to the formation of a neuroepithelium. In later stages of retina regeneration, the BMP pathway inhibits the FGF pathway and signals through a non-canonical pathway, promoting cell death.
Katia Del Rio-Tsonis, PhD (Advisor)
Paul James, PhD (Committee Member)
Paul Harding, PhD (Committee Member)
Biology; Cellular Biology; Molecular Biology
retina; regeneration; BMP

Recommended Citations

Citations

  • Gutierrez, C. (2008). The BMP pathway: Its role in retina regeneration [Master's thesis, Miami University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=miami1228837408

    APA Style (7th edition)

  • Gutierrez, Christian. The BMP pathway: Its role in retina regeneration. 2008. Miami University, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=miami1228837408.

    MLA Style (8th edition)

  • Gutierrez, Christian. "The BMP pathway: Its role in retina regeneration." Master's thesis, Miami University, 2008. http://rave.ohiolink.edu/etdc/view?acc_num=miami1228837408

    Chicago Manual of Style (17th edition)

miami1228837408
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© 2008, all rights reserved.
This open access ETD is published by Miami University and OhioLINK.