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Cerebellar theta oscillations are synchronized during hippocampal theta-contingent trace conditioning

Hoffmann, Loren C.
http://rave.ohiolink.edu/etdc/view?acc_num=miami1251998588

Abstract Details

2009, Master of Arts, Miami University, Psychology.
The hippocampus and cerebellum are critically involved in trace eyeblink classical conditioning (EBCC). The mechanisms underlying the hippocampal-cerebellar interaction during this task are not well understood, although hippocampal theta (3-7 Hz) oscillations are known to reflect a favorable state for EBCC. Two groups of rabbits received trace EBCC in which a brain-computer interface administered trials in either the explicit presence or absence of naturally occurring hippocampal theta. A high percentage of robust theta led to a striking enhancement of learning accompanied by rhythmic theta-band (6-7 Hz) oscillations in the interpositus nucleus (IPN) and cerebellar cortex that were time-locked both to hippocampal rhythms and sensory stimuli during training. Rhythmic activity was absent in the cerebellum of the non-theta group. These data strongly suggest a beneficial impact of theta-based coordination of hippocampus and cerebellum and, importantly, demonstrate that hippocampal theta oscillations can be used to regulate the functional properties of the cerebellum.
Stephen Berry, PhD (Advisor)
Jennifer Quinn, PhD (Committee Member)
Dragana Ivkovich Claflin, PhD (Committee Member)
42 p.
Psychobiology
associative learning; eyeblink classical conditioning; hippocampus; cerebellum; theta; oscillations; synchronization; electrophysiology; local field potentials; brain-computer interface; rabbit

Recommended Citations

Citations

  • Hoffmann, L. C. (2009). Cerebellar theta oscillations are synchronized during hippocampal theta-contingent trace conditioning [Master's thesis, Miami University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=miami1251998588

    APA Style (7th edition)

  • Hoffmann, Loren. Cerebellar theta oscillations are synchronized during hippocampal theta-contingent trace conditioning. 2009. Miami University, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=miami1251998588.

    MLA Style (8th edition)

  • Hoffmann, Loren. "Cerebellar theta oscillations are synchronized during hippocampal theta-contingent trace conditioning." Master's thesis, Miami University, 2009. http://rave.ohiolink.edu/etdc/view?acc_num=miami1251998588

    Chicago Manual of Style (17th edition)

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© 2009, all rights reserved.
This open access ETD is published by Miami University and OhioLINK.