Skip to Main Content
Frequently Asked Questions
Submit an ETD
Global Search Box
Need Help?
Keyword Search
Participating Institutions
Advanced Search
School Logo
Files
File List
miami1281124967.pdf (1.08 MB)
ETD Abstract Container
Abstract Header
BIOINFORMATICS ANALYSIS OF ALTERNATIVE SPLICING IN CHLAMYDOMONAS REINHARDTII
Author Info
Raj Kumar, Praveen Kumar
Permalink:
http://rave.ohiolink.edu/etdc/view?acc_num=miami1281124967
Abstract Details
Year and Degree
2010, Master of Science, Miami University, Botany.
Abstract
Pre-mRNA splicing is one of the fundamental post-transcriptional processes in eukaryotic gene expression and regulation. Alternative Splicing (AS) occurs when different splice sites of pre-mRNA are processed to generate mRNA isoforms leading to diverse proteins with functional and/or structural differences from the same gene. The first chapter of my thesis gives a mini review on alternative splicing in plants. The second chapter reports the finding on the bioinformatics analysis of alternative splicing in Chlamydomonas reinhardtii. Unlike in mammals, intron retention is the major mode of alternative splicing in plants, suggesting distinctive regulatory mechanisms of AS between plants and animals. Chlamydomonas reinhardtii, an alga that shares both animal and plant traits serves a good model to study evolutionary perspective of AS and its underlying mechanisms. In this alga, retained introns are significantly shorter and have weaker splice sites, with fewer G-triplets intronic splicing enhancers and C-triplets than constitutively spliced introns.
Committee
Chun Liang, Dr (Advisor)
Qingshun Quinn Li, Dr (Committee Member)
John E. Karro, Dr (Committee Member)
Pages
67 p.
Subject Headings
Bioinformatics
;
Biology
Keywords
retained intron
;
alternative splicing
;
chlamy
;
intronic splicing enhancer
Recommended Citations
Refworks
EndNote
RIS
Mendeley
Citations
Raj Kumar, P. K. (2010).
BIOINFORMATICS ANALYSIS OF ALTERNATIVE SPLICING IN CHLAMYDOMONAS REINHARDTII
[Master's thesis, Miami University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=miami1281124967
APA Style (7th edition)
Raj Kumar, Praveen Kumar.
BIOINFORMATICS ANALYSIS OF ALTERNATIVE SPLICING IN CHLAMYDOMONAS REINHARDTII.
2010. Miami University, Master's thesis.
OhioLINK Electronic Theses and Dissertations Center
, http://rave.ohiolink.edu/etdc/view?acc_num=miami1281124967.
MLA Style (8th edition)
Raj Kumar, Praveen Kumar. "BIOINFORMATICS ANALYSIS OF ALTERNATIVE SPLICING IN CHLAMYDOMONAS REINHARDTII." Master's thesis, Miami University, 2010. http://rave.ohiolink.edu/etdc/view?acc_num=miami1281124967
Chicago Manual of Style (17th edition)
Abstract Footer
Document number:
miami1281124967
Download Count:
678
Copyright Info
© 2010, all rights reserved.
This open access ETD is published by Miami University and OhioLINK.