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Identified Interneurons of Dorsal Hippocampal Area CA1 Show Different Theta-Contingent Response Profiles During Classical Eyeblink Conditioning

Cicchese, Joseph J
http://orcid.org/0000-0003-2128-0702
http://rave.ohiolink.edu/etdc/view?acc_num=miami1367583089

Abstract Details

2013, Master of Arts, Miami University, Psychology.
Hippocampal interneurons are a heterogeneous group with identifiable subtypes. The present study utilized tetrode recordings and a brain-computer interface (BCI) to examine response profiles of five interneuron types (axo-axonic, basket, bistratified, cholecystokinin-expressing, and oriens-lacunosum-moleculare cells) during trace eyeblink conditioning in the rabbit. The BCI initiated trials in the presence (T+) or absence (T-) of hippocampal theta, a methodology previously shown to affect learning rate. In various trial epochs, T+ axo-axonic and basket cells showed greater responses than those in T-, while T- oriens-lacunosum-moleculare cells showed greater responses than in T+. Such response profiles are consistent with models proposing a role for theta in storage vs. retrieval functions of the hippocampus. These data suggest theta modulation of distinct responses of interneuron subtypes, and support the idea that the naturally occurring theta rhythm can affect information processing by the hippocampus in ways that cause a significant improvement in behavioral learning rate.
Stephen Berry, PhD (Committee Chair)
Barbara Oswald, PhD (Committee Member)
Jennifer Quinn, PhD (Committee Member)
44 p.
Neurobiology; Psychobiology
eyeblink classical conditioning; hippocampus; theta; electrophysiology; single-unit; interneuron; brain-computer interface

Recommended Citations

Citations

  • Cicchese, J. J. (2013). Identified Interneurons of Dorsal Hippocampal Area CA1 Show Different Theta-Contingent Response Profiles During Classical Eyeblink Conditioning [Master's thesis, Miami University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=miami1367583089

    APA Style (7th edition)

  • Cicchese, Joseph. Identified Interneurons of Dorsal Hippocampal Area CA1 Show Different Theta-Contingent Response Profiles During Classical Eyeblink Conditioning. 2013. Miami University, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=miami1367583089.

    MLA Style (8th edition)

  • Cicchese, Joseph. "Identified Interneurons of Dorsal Hippocampal Area CA1 Show Different Theta-Contingent Response Profiles During Classical Eyeblink Conditioning." Master's thesis, Miami University, 2013. http://rave.ohiolink.edu/etdc/view?acc_num=miami1367583089

    Chicago Manual of Style (17th edition)

miami1367583089
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© 2013, all rights reserved.
This open access ETD is published by Miami University and OhioLINK.