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Fotouh_dissertation_July_16_Final.pdf (5.79 MB)

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Determination of organic ions and pharmaceuticals by flow injection analysis and ion exclusion chromatography

Mansour, Fotouh Rashed
http://rave.ohiolink.edu/etdc/view?acc_num=miami1374081147

Abstract Details

2013, Doctor of Philosophy, Miami University, Chemistry and Biochemistry.
This dissertation consists of two parts, each of which addresses a different analytical technique: Part I, Flow Injection Analysis (FIA), includes three chapters: Chapter 1, Reverse Flow Injection Analysis (rFIA), is a review about one of the FIA modes that can be used to minimize reagent consumption, decrease sample dispersion, and enhance the sensitivity. Chapter 2, Flow Injection Determination of Carboxylate, Phosphate, and Sulfhydryl Compounds using Exchange Complexation, addresses exploiting the decrease in absorbance of the Fe(III)-salicylate complex due to preferential ligand interaction with ferric ion for quantitative analysis. Chapter 3, Indirect Detection in FIA, is a review that discusses the different methods reported for the optimization of FIA applications based on indirect detection together with another proposed method of optimization. Part II, Ion Exclusion Chromatography (IELC), includes six chapters: Chapter 4, IELC of Aromatic Acids, is a review that discusses the retention mechanisms as well as the factors affecting retention, eluents, and detection methods used in IELC of aromatic acids. Chapter 5, Separation of Aliphatic and Aromatic Carboxylic Acids by Conventional and Ultra High Performance (UHP)-IELC, addresses an IELC comparison between a conventional ion exchange column and a UHPLC dynamically modified C18 column for the separation of an aliphatic carboxylic acid and two aromatic carboxylic acids. Chapter 6, Multimodal Liquid Chromatography (MMLC) of Small Molecules, is reviewing the different applications of MMLC in medical, pharmaceutical, and industrial analysis of small molecules. Chapter 7, Determination of Carnitine and Acylcarnitines in Biological Samples, is a review about the different separation methods of carnitine and acylcarnitines in addition to the sample preparation and the different derivatization reactions. Chapter 8, Separation of Carnitine and Acetylcarnitine by Mixed Mode Ion Exchange/Ion Exclusion Liquid Chromatography, proposes a simple and fast MMLC method for determination of total and free carnitine in human serum. The method is based on separation of free carnitine from acetic acid and acetylcarnitine by a mixed mode IEC/IELC technique. Chapter 9, Separation of Unfractionated Heparin and Other Glycosaminoglycans (GAGs) using Ion Exclusion Chromatography, introduces IELC as an alternative to the pharmacopeial method to separate oversulfated chondroitin sulfate from heparin and other GAGs.
Neil Danielson, PhD (Advisor)
André Sommer, PhD (Committee Chair)
Jonathan Scaffidi, PhD (Committee Member)
Hong Wang, PhD (Committee Member)
Kathleen Killian, PhD (Committee Member)
263 p.
Chemistry
flow injection analysis; ion exclusion chromatography

Recommended Citations

Citations

  • Mansour, F. R. (2013). Determination of organic ions and pharmaceuticals by flow injection analysis and ion exclusion chromatography [Doctoral dissertation, Miami University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=miami1374081147

    APA Style (7th edition)

  • Mansour, Fotouh. Determination of organic ions and pharmaceuticals by flow injection analysis and ion exclusion chromatography . 2013. Miami University, Doctoral dissertation. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=miami1374081147.

    MLA Style (8th edition)

  • Mansour, Fotouh. "Determination of organic ions and pharmaceuticals by flow injection analysis and ion exclusion chromatography ." Doctoral dissertation, Miami University, 2013. http://rave.ohiolink.edu/etdc/view?acc_num=miami1374081147

    Chicago Manual of Style (17th edition)

miami1374081147
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© 2013, all rights reserved.
This open access ETD is published by Miami University and OhioLINK.