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OL_Thesis_Rosa Akbarzadeh_2013.pdf (1.51 MB)

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Developing Hierarchical Polymeric Scaffolds for Bone Tissue Engineering

Akbarzadeh, Rosa
http://rave.ohiolink.edu/etdc/view?acc_num=miami1376962498

Abstract Details

2013, Master of Science, Miami University, Chemical, Paper and Biomedical Engineering.
Tissue engineering makes use of the principles of biology and engineering to develop 3D scaffolds to sustain 3D cell growth, and promote the tissue repair and/or regeneration. The current trend in developing tissue-engineering scaffolds is to use computer aided design combined with solid freeform fabrication (SFF) techniques. This is primarily because the control over scaffold microstructure using conventional techniques is highly process driven, which does not allow a rigorous control over scaffold architecture. However, combining the design-driven macropores with process-driven micropores can lead to hierarchical scaffold architectures with enhanced cell migration and a more efficient transport of oxygen and nutrients. This work introduces a hybrid SFF-TIPS technique to produce scaffolds with bimodal pore size distribution. In this study, poly(lactic-co-glycolic acid) (PLGA) was used to fabricate the hierarchical constructs. The produced scaffolds from thermally induced phase separation (TIPS) contained micropores, with interconnected channels, generated by the solid freeform fabrication technique. We examined the effect of SFF and TIPS parameters on pore structure, porosity, and mechanical properties. The in vitro studies using the MC3T3-E1 osteoblastic cell line enabled us to evaluate the cell growth outcomes for these macro/microporous constructs.
Azizeh Yousefi Moshirabad, PhD (Advisor)
Paul F. James, PhD (Advisor)
Jessica Sparks, PhD (Committee Member)
79 p.
Biomedical Engineering; Biomedical Research; Chemical Engineering
PLGA scaffold, solid freeform fabrication, thermally induced phase separation, bimodal pore size distribution, bone tissue engineering

Recommended Citations

Citations

  • Akbarzadeh, R. (2013). Developing Hierarchical Polymeric Scaffolds for Bone Tissue Engineering [Master's thesis, Miami University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=miami1376962498

    APA Style (7th edition)

  • Akbarzadeh, Rosa. Developing Hierarchical Polymeric Scaffolds for Bone Tissue Engineering. 2013. Miami University, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=miami1376962498.

    MLA Style (8th edition)

  • Akbarzadeh, Rosa. "Developing Hierarchical Polymeric Scaffolds for Bone Tissue Engineering." Master's thesis, Miami University, 2013. http://rave.ohiolink.edu/etdc/view?acc_num=miami1376962498

    Chicago Manual of Style (17th edition)

miami1376962498
174
© 2013, all rights reserved.
This open access ETD is published by Miami University and OhioLINK.