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DISPERSION OF GEOMETRIC TITANIUM DIOXIDE NANOMATERIALS AND THEIR BIOLOGIC EFFECT

Tilly, Trevor

Abstract Details

2013, Master of Science, Miami University, Chemical, Paper and Biomedical Engineering.
Tunable chemical and physical properties of engineered nanomaterials are achievable by changing their geometry and morphology. Titanium dioxide (TiO2) based nanofilaments-nanotube, nanowire, nanorod-have gained interest in industrial, energy, and as of recent, medical applications due to their superior performance over TiO2 nanoparticles. Safety assessment of these nanomaterials is critical to protect workers, patients, and bystanders as these technologies become widely implemented. Additionally, TiO2 based nanofilaments can easily be inhaled by humans and their high aspect ratio may make them toxic in the air passageway, like asbestos fibers. The tendency of TiO2 nanofilaments to aggregate makes their nanotoxicity assessment difficult and the results controversial because incomplete dispersion results in larger particle size exposure that is no longer at the nanoscale. In this study, a microfluidic device was utilized to produce stable dosing solutions necessary to evaluate the toxicity of TiO2 nanomaterials by eliminating any toxicity caused by aggregated TiO2 nanomaterials. The toxicity results could then be directly correlated to the TiO2 nanostructure itself. Well dispersed TiO2 based nanomaterials were nontoxic to cells. Whereas, aggregated 100 ug/ml concentrations of nanowires and nanotubes reduced viability up to 27%, indicating that in vitro toxicity results may be controlled by the dispersion of dosing solutions.
Lei Kerr, PhD (Advisor)
Saber Hussain, PhD (Advisor)
Catherine Almquist, PhD (Committee Member)
Justin Saul, PhD (Committee Member)
36 p.

Recommended Citations

Citations

  • Tilly, T. (2013). DISPERSION OF GEOMETRIC TITANIUM DIOXIDE NANOMATERIALS AND THEIR BIOLOGIC EFFECT [Master's thesis, Miami University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=miami1387488387

    APA Style (7th edition)

  • Tilly, Trevor. DISPERSION OF GEOMETRIC TITANIUM DIOXIDE NANOMATERIALS AND THEIR BIOLOGIC EFFECT. 2013. Miami University, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=miami1387488387.

    MLA Style (8th edition)

  • Tilly, Trevor. "DISPERSION OF GEOMETRIC TITANIUM DIOXIDE NANOMATERIALS AND THEIR BIOLOGIC EFFECT." Master's thesis, Miami University, 2013. http://rave.ohiolink.edu/etdc/view?acc_num=miami1387488387

    Chicago Manual of Style (17th edition)