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Thesis_Fitzgerald_Final.pdf (2.22 MB)

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Development and 3D Printing of Interpenetrating Network Hydrogel Materials for use as Tissue-Mimetic Models

Fitzgerald, Martha Moore
http://orcid.org/0000-0002-6572-2210
http://rave.ohiolink.edu/etdc/view?acc_num=miami1430488189

Abstract Details

2015, Master of Science, Miami University, Chemical, Paper and Biomedical Engineering.
This thesis reports the development, and subsequent 3D printing, of a two-part polyacrylamide-alginate interpenetrating network (IPN) hydrogel material with tissue-mimetic properties. Two possible applications include medical simulation and tissue engineering. Material development was performed with single-parameter chemical concentration variations from a baseline formula to establish mechanical property trends. The concentrations of total monomer material and acrylamide crosslinker have the largest effect on elastic modulus and stress relaxation behavior, respectively. Results demonstrate that these hydrogels can be tuned to closely mimic both the elastic and viscoelastic behaviors of muscle tissue. Hardware alterations to a 3D printer allowed the two-part solution to be rapidly printed with high shape fidelity and similar mechanical properties to native tissue at a relatively low cost and on a large scale. The alginate-polyacrylamide material can be tuned in its bulk state, and 3D printed into constructs that are in the correct scale for use in tissue-mimetic applications.
Jessica Sparks, PhD (Advisor)
Jason Berberich, PhD (Committee Member)
Justin Saul , PhD (Committee Member)
104 p.
Biomedical Engineering; Chemical Engineering
Hydrogel; Interpenetrating network; stress relaxation; Muscle; tissue-mimetic; alginate-polyacrylamide; 3D printing; Viscoelastic; Simulation

Recommended Citations

Citations

  • Fitzgerald, M. M. (2015). Development and 3D Printing of Interpenetrating Network Hydrogel Materials for use as Tissue-Mimetic Models [Master's thesis, Miami University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=miami1430488189

    APA Style (7th edition)

  • Fitzgerald, Martha. Development and 3D Printing of Interpenetrating Network Hydrogel Materials for use as Tissue-Mimetic Models. 2015. Miami University, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=miami1430488189.

    MLA Style (8th edition)

  • Fitzgerald, Martha. "Development and 3D Printing of Interpenetrating Network Hydrogel Materials for use as Tissue-Mimetic Models." Master's thesis, Miami University, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=miami1430488189

    Chicago Manual of Style (17th edition)

miami1430488189
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© 2015, all rights reserved.
This open access ETD is published by Miami University and OhioLINK.