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Computational Design and Optimization of Bone Tissue Engineering Scaffold Topology

Uth, Nicholas P
http://orcid.org/0000-0003-0065-2132
http://rave.ohiolink.edu/etdc/view?acc_num=miami1452783077

Abstract Details

2016, Master of Science, Miami University, Chemical, Paper and Biomedical Engineering.
Bone tissue engineering aims to help the body naturally regenerate critical sized defects (and non-unions) that would otherwise require bone grafts. Scaffolds are a vital tool in this field, as they act as temporary matrices for cellular adhesion and bear mechanical loads during patient recovery. However, there are many aspects to designing such scaffolds, and two of the most vital (compressive modulus and porosity) conflict. Commonly, studies that attempt to determine viable designs use "trial-and-error" methods, which are resource demanding and may not guarantee fully optimized results. In this study, we sought to generate a scaffold topology that satisfied the compressive modulus and porosity requirements for trabecular bone regeneration with COMSOL optimization software. To determine the validity of COMSOL’s optimized topology and predicted behavior, we constructed and tested 24 scaffolds via 3D bioplotting, an additive manufacturing technique, according to a physical I-optimal split-plot designed experiment. The results were used to generate response surface methodology models that could be used to optimize scaffold topology and predict the resultant compressive modulus and porosity.
Azizeh-Mitra Yousefi (Advisor)
Byran Smucker (Advisor)
Jens Mueller (Committee Member)
Andrew Paluch (Committee Member)
Biomedical Engineering
bone tissue engineering; 3D bioplotting; additive manufacturing; topology; optimization; simulation; COMSOL; designed experiment

Recommended Citations

Citations

  • Uth, N. P. (2016). Computational Design and Optimization of Bone Tissue Engineering Scaffold Topology [Master's thesis, Miami University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=miami1452783077

    APA Style (7th edition)

  • Uth, Nicholas. Computational Design and Optimization of Bone Tissue Engineering Scaffold Topology. 2016. Miami University, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=miami1452783077.

    MLA Style (8th edition)

  • Uth, Nicholas. "Computational Design and Optimization of Bone Tissue Engineering Scaffold Topology." Master's thesis, Miami University, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=miami1452783077

    Chicago Manual of Style (17th edition)

miami1452783077
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© 2016, all rights reserved.
This open access ETD is published by Miami University and OhioLINK.