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nishiik_MasterThesis_Apr29_final3.pdf (7.3 MB)

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MICRO-SCALE FLUID DYNAMICS AND ITS EFFECT ON HEPATIC PROGENITOR CELL REGENERATION ACTIVATION

Nishii, Kenichiro
http://orcid.org/0000-0002-0820-0213
http://rave.ohiolink.edu/etdc/view?acc_num=miami1461945701

Abstract Details

2016, Master of Science, Miami University, Chemical, Paper and Biomedical Engineering.
The liver has a variety of integral biological functions in the body, and is also known for its ability for regeneration. However, the detailed mechanism of the liver regeneration process has remained unclear due to the complex fluid environment at the macro- and microscopic levels. In particular, the relationship between liver regeneration activation and change in fluid environment is not well understood. In this thesis, organ scale liver vasculature was modeled in an electric circuit analog model and microscopic tissue scale liver pore viscoelastic structure was modeled in a finite element model in order to understand complex fluid dynamics within native and decellularized liver tissue. Also, shear flow was applied to 2D and 3D cultured hepatic progenitor cells in extracellular matrix hydrogel to see the effect of shear stress on hepatic progenitor cell regeneration activation. It was found that the electric circuit analog model could successfully reproduce fluid pressure measurements in native and decellularized liver, and provide information for the finite element model to simulate microscopic fluid dynamics. In addition, up regulation of regeneration related genes was observed after shear stress application to cultured cells. Those findings combined together can provide a better insight into successful liver regeneration methodology.
Jessica Sparks, Ph.D. (Advisor)
Justin Saul, Ph.D. (Committee Member)
Greg Reese, Ph.D. (Committee Member)
Coffin Douglas , Ph.D. (Committee Member)
109 p.
Biomedical Engineering
Shear Stress, BMOL, Computational Model, Decellularization, Biomechanics, Liver, Electric Analog, Finite Element

Recommended Citations

Citations

  • Nishii, K. (2016). MICRO-SCALE FLUID DYNAMICS AND ITS EFFECT ON HEPATIC PROGENITOR CELL REGENERATION ACTIVATION [Master's thesis, Miami University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=miami1461945701

    APA Style (7th edition)

  • Nishii, Kenichiro. MICRO-SCALE FLUID DYNAMICS AND ITS EFFECT ON HEPATIC PROGENITOR CELL REGENERATION ACTIVATION. 2016. Miami University, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=miami1461945701.

    MLA Style (8th edition)

  • Nishii, Kenichiro. "MICRO-SCALE FLUID DYNAMICS AND ITS EFFECT ON HEPATIC PROGENITOR CELL REGENERATION ACTIVATION." Master's thesis, Miami University, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=miami1461945701

    Chicago Manual of Style (17th edition)

miami1461945701
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© 2016, all rights reserved.
This open access ETD is published by Miami University and OhioLINK.