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Synthesis of XZH-5 Derivatives as Inhibitors of Signal Transducer and Activator of Transcription 3 (STAT3) and Synthesis of π-Extended Tetraphenylporphyrins

Altundas, Abdullah Bilal

Abstract Details

2016, Master of Science, Miami University, Chemistry and Biochemistry.
This thesis is comprised of four chapters: Chapter zero gives a brief introduction and points to the importance of this work. Chapter one includes an introduction to Signal Transducer and Activator of Transcription 3 proteins and its activation in cancerous cells. Various inhibitors have been synthesized and will be tested in due course for their biological activity. The design and synthesis of these inhibitors derived from readily available and inexpensive starting materials are summarized in hopeful pursuit to attaining possible building blocks for anti-cancer drugs. Chapter two includes an introduction to highly aromatic and intensely absorbing heterocyclic macrocycles known as porphyrins. Synthesis of π-extended tetraphenylporphyrins with styrene derivatives from their β-β’ positions using a concise three-step method is summarized. The successful synthesis of free base mono- and dibenzotetraphenylporphyrins is described using a dual catalyst system. These molecules are obtained with the hope that they can be applied in various areas such as molecular electronics and nanotechnology. Chapter three includes a summarization of this work and describes possible future work that will be carried out with results obtained from the two individual projects.
Dominik Konkolewicz (Committee Chair)
Hong Wang (Advisor)
Scott Hartley (Committee Member)
Rick Page (Committee Member)
98 p.

Recommended Citations

Citations

  • Altundas, A. B. (2016). Synthesis of XZH-5 Derivatives as Inhibitors of Signal Transducer and Activator of Transcription 3 (STAT3) and Synthesis of π-Extended Tetraphenylporphyrins [Master's thesis, Miami University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=miami1473201129

    APA Style (7th edition)

  • Altundas, Abdullah . Synthesis of XZH-5 Derivatives as Inhibitors of Signal Transducer and Activator of Transcription 3 (STAT3) and Synthesis of π-Extended Tetraphenylporphyrins . 2016. Miami University, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=miami1473201129.

    MLA Style (8th edition)

  • Altundas, Abdullah . "Synthesis of XZH-5 Derivatives as Inhibitors of Signal Transducer and Activator of Transcription 3 (STAT3) and Synthesis of π-Extended Tetraphenylporphyrins ." Master's thesis, Miami University, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=miami1473201129

    Chicago Manual of Style (17th edition)