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MU Doctoral Dissertation WRC1.pdf (13.7 MB)

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Evaluation of zinc binding groups (ZBGs) as inhibitor building blocks using carbonic anhydrase and the catalytic domain of matrix metalloproteinase 12 (cdMMP-12)

Craig, Whitney Richert
http://orcid.org/0000-0002-4138-1415
http://rave.ohiolink.edu/etdc/view?acc_num=miami1500311991462216

Abstract Details

2017, Doctor of Philosophy, Miami University, Chemistry and Biochemistry.
Carbonic anhydrase (CA) was used as a model for matrix metalloproteinases (MMPs). CA is a more ubiquitous protein that binds zinc in the same manner as MMPs, His3(OH). Current MMP inhibitors target both unregulated and normal functioning MMPs at the catalytic Zn(II) site, but show minimal specificity and high toxicity. A new class of inhibitor building blocks are being evaluated as potential MMP inhibitor scaffolds, based on their interactions with Zn- and Co-containing CA.
David Tierney (Advisor)
Michael Crowder (Committee Member)
A. Carole Dabney-Smith (Committee Member)
Stacey Bretz (Committee Member)
Jiangjiang Zhu (Committee Member)
149 p.
Chemistry
carbonic anhydrase; matrix metalloproteinase 12; zinc binding groups;

Recommended Citations

Citations

  • Craig, W. R. (2017). Evaluation of zinc binding groups (ZBGs) as inhibitor building blocks using carbonic anhydrase and the catalytic domain of matrix metalloproteinase 12 (cdMMP-12) [Doctoral dissertation, Miami University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=miami1500311991462216

    APA Style (7th edition)

  • Craig, Whitney. Evaluation of zinc binding groups (ZBGs) as inhibitor building blocks using carbonic anhydrase and the catalytic domain of matrix metalloproteinase 12 (cdMMP-12). 2017. Miami University, Doctoral dissertation. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=miami1500311991462216.

    MLA Style (8th edition)

  • Craig, Whitney. "Evaluation of zinc binding groups (ZBGs) as inhibitor building blocks using carbonic anhydrase and the catalytic domain of matrix metalloproteinase 12 (cdMMP-12)." Doctoral dissertation, Miami University, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=miami1500311991462216

    Chicago Manual of Style (17th edition)

miami1500311991462216
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© 2017, all rights reserved.
This open access ETD is published by Miami University and OhioLINK.