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CYCLIC VOLTAMMETRIC DETERMINATION OF 17-α-ETHINYL ESTRADIOL ON DISPOSABLE SCREEN-PRINTED CARBON ELECTRODES

Abstract Details

2019, Master of Science, Miami University, Chemical, Paper and Biomedical Engineering.
A quick and easy method for determining concentrations of 17-α-Ethinyl Estradiol is through the use of an electrochemical method utilizing disposable screen-printed carbon electrodes. The electrochemical behavior of 17-α-Ethinyl Estradiol was investigated by cyclic voltammetry. The oxidation reaction occurs on the screen-printed carbon electrode and the linear response of 17-α-Ethinyl Estradiol is obtained for the concentration range of 3×10-5 M (8900 μg/L) to 3×10-6 M (890 μg/L) with an achieved sensitivity of 0.1714 μA/μM. The experimentally determined detection limit of this electrode is measured to be 2×10-7 M (59.2 μg/L). The repeatability of this method, (Relative Standard Deviation) %, was conducted on concentrations of 1×10-5 M (2368.3 μg/L) and 3×10-6 M (890 μg/L) with respective RSD% values of 5.11% and 13.72% (n=5). The performance of different pH values (from pH 4-10) for 17-α-Ethinyl Estradiol was also investigated. It was determined that pH 6.8 gives the best electrochemical behavior. Selectivity of this method is validated and screen-printed carbon electrodes are able to detect 17-α-Ethinyl Estradiol with the presence of interferences. The proposed method for determines 17-α-Ethinyl Estradiol is simple and fast.
Lei Kerr (Advisor)
Shashi Lalvani (Advisor)
Hang Ren (Committee Member)
44 p.

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Citations

  • Qian, Z. (2019). CYCLIC VOLTAMMETRIC DETERMINATION OF 17-α-ETHINYL ESTRADIOL ON DISPOSABLE SCREEN-PRINTED CARBON ELECTRODES [Master's thesis, Miami University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=miami1565371346943373

    APA Style (7th edition)

  • Qian, Zepeng. CYCLIC VOLTAMMETRIC DETERMINATION OF 17-α-ETHINYL ESTRADIOL ON DISPOSABLE SCREEN-PRINTED CARBON ELECTRODES. 2019. Miami University, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=miami1565371346943373.

    MLA Style (8th edition)

  • Qian, Zepeng. "CYCLIC VOLTAMMETRIC DETERMINATION OF 17-α-ETHINYL ESTRADIOL ON DISPOSABLE SCREEN-PRINTED CARBON ELECTRODES." Master's thesis, Miami University, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=miami1565371346943373

    Chicago Manual of Style (17th edition)