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Body Composition and Adipokine Levels in Growth Hormone Antagonist Mice

Magon, Vishakha
http://rave.ohiolink.edu/etdc/view?acc_num=ohiou1244481356

Abstract Details

2009, Master of Science (MS), Ohio University, Food and Nutrition (Health and Human Services).
The study examined age- and gender-related changes in body weight, body composition (6 to 80 weeks of age), fasting blood glucose level, and plasma leptin level (8, 13, 26, 52, and 72 weeks) in male and female growth hormone antagonist (GHA) transgenic mice in comparison to their wild-type (WT) littermate mice. Tissue and organ weights were also assessed at the conclusion of the study. Results showed that male GHA mice approached the weight of male WT mice during the later phase of life but female GHA mice always weighed significantly less than their controls. GHA mice of both genders exhibited lower lean mass, higher fat mass, and higher serum leptin level with advancing age. Euglycemia was exhibited in GHA mice and this trend was evident throughout the period of study. Higher subcutaneous (absolute and percent) and retroperitoneal (absolute) fat pad and lower organ weights (absolute: all organs; percent: heart, kidney, muscle) were found in GHA mice when compared to controls.
Darlene E. Berryman, PhD (Advisor)
Shigeru Okada, PhD (Committee Member)
Fang Meng, PhD (Committee Member)
173 p.
Nutrition
Adipokine; Adipose tissue; Body composition; Growth Hormone Antagonist; Leptin

Recommended Citations

Citations

  • Magon, V. (2009). Body Composition and Adipokine Levels in Growth Hormone Antagonist Mice [Master's thesis, Ohio University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=ohiou1244481356

    APA Style (7th edition)

  • Magon, Vishakha. Body Composition and Adipokine Levels in Growth Hormone Antagonist Mice. 2009. Ohio University, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=ohiou1244481356.

    MLA Style (8th edition)

  • Magon, Vishakha. "Body Composition and Adipokine Levels in Growth Hormone Antagonist Mice." Master's thesis, Ohio University, 2009. http://rave.ohiolink.edu/etdc/view?acc_num=ohiou1244481356

    Chicago Manual of Style (17th edition)

ohiou1244481356
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© 2009, all rights reserved.
This open access ETD is published by Ohio University and OhioLINK.