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ohiou1288578177.pdf (1.78 MB)
ETD Abstract Container
Abstract Header
Computational Methods for Cis-Regulatory Module Discovery
Author Info
Liang, Xiaoyu
Permalink:
http://rave.ohiolink.edu/etdc/view?acc_num=ohiou1288578177
Abstract Details
Year and Degree
2010, Master of Science (MS), Ohio University, Computer Science (Engineering and Technology).
Abstract
In a gene regulation network, the action of a transcription factor binding a short region in non-coding sequence is reported and believed as the key that triggers, or represses genes' expression. Further analysis revealed that, in higher organisms, multiple transcription factors work together and bind multiple sites that are located nearby in genomic sequences, rather than working alone and binding a single anchor. These multiple binding sites in the non-coding region are called cis-regulatory modules. Identifying these cis-regulatory modules is important for modeling gene regulation network. In this thesis, two methods have been proposed for addressing the problem, and a widely accepted evaluation was applied for assessing the performance. Additionally, two practical case studies were completed and reported as the application of the proposed methods.
Committee
Lonnie Welch (Advisor)
Frank Drews (Committee Member)
Razvan Bunescu (Committee Member)
Sarah Wyatt (Committee Member)
Subject Headings
Computer Science
Keywords
gene regulation network
;
transcription factor
;
non-coding sequence
;
gener expression
;
genomic sequences
;
cis-regulatory modules
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Citations
Liang, X. (2010).
Computational Methods for Cis-Regulatory Module Discovery
[Master's thesis, Ohio University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=ohiou1288578177
APA Style (7th edition)
Liang, Xiaoyu.
Computational Methods for Cis-Regulatory Module Discovery.
2010. Ohio University, Master's thesis.
OhioLINK Electronic Theses and Dissertations Center
, http://rave.ohiolink.edu/etdc/view?acc_num=ohiou1288578177.
MLA Style (8th edition)
Liang, Xiaoyu. "Computational Methods for Cis-Regulatory Module Discovery." Master's thesis, Ohio University, 2010. http://rave.ohiolink.edu/etdc/view?acc_num=ohiou1288578177
Chicago Manual of Style (17th edition)
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Document number:
ohiou1288578177
Download Count:
668
Copyright Info
© 2010, all rights reserved.
This open access ETD is published by Ohio University and OhioLINK.