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Effect of Nitric Oxide on Myeloid Dendritic Cell Adhesion

Abstract Details

2012, Master of Science (MS), Ohio University, Biomedical Engineering (Engineering and Technology).
Cell adhesion and motility are controlled by the interplay between the dynamics of actin cytoskeleton and the formation/disassembly of cell-matrix adhesion area. Dendritic cells (DCs), known as the initiators and modulators of innate and adaptive immunities, can migrate from peripheral tissues to lymph nodes (LN) after antigen challenge. However, the mechanism of how DCs manage to leave the tissue sites is not fully understood. Some previous in vitro studies on bone marrow-derived myeloid DCs suggest (1) in static cell culture systems, cellular production of inducible nitric oxide (NO) by mature DCs plays a role in decreasing adherence between these cells to extracellular matrix components (ECM); (2) NO inhibition restores adhesion events, especially on fibronectin. In this thesis, we try to uncover the way in which DCs decrease adhesive property to ECM after encountering foreign antigens. We found NO is involved in regulating the distribution of cytoskeleton and the expression protein kinases at the focal adhesion sites, suggesting the capability of NO in decreasing the adhesive properties of DCs.
Fabian Benencia (Advisor)
Douglas Goetz (Committee Chair)
Monica Burdick (Committee Member)
Ramiro Malgor (Committee Member)

Recommended Citations

Citations

  • Gu, M. (2012). Effect of Nitric Oxide on Myeloid Dendritic Cell Adhesion [Master's thesis, Ohio University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=ohiou1338903998

    APA Style (7th edition)

  • Gu, Mingyu. Effect of Nitric Oxide on Myeloid Dendritic Cell Adhesion. 2012. Ohio University, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=ohiou1338903998.

    MLA Style (8th edition)

  • Gu, Mingyu. "Effect of Nitric Oxide on Myeloid Dendritic Cell Adhesion." Master's thesis, Ohio University, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=ohiou1338903998

    Chicago Manual of Style (17th edition)