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Discovery of Putative STAT5 Transcription Factor Binding Sites in Mice with Diabetic Nephropathy

Schmidt, Jens
http://rave.ohiolink.edu/etdc/view?acc_num=ohiou1385482459

Abstract Details

2013, Master of Science (MS), Ohio University, Computer Science (Engineering and Technology).
Type 1 diabetes mellitus has become a major disease and impacts patients' lives significantly. Because the underlying pathways and the genetic causes have not been exhaustively examined yet, this thesis focuses on identifying potential binding sites for STAT5, a transcription factor that is hypothesized to play a role in the inflammation process of diabetic nephropathy, a complication of type 1 diabetes. In this study, motif finding was applied to determine a set of putative STAT5 binding sites. This set was filtered by comparison to three gene ontology terms that are associated with processes that can occur in diabetic nephropathy and by comparison to experimentally validated STAT5 binding sites. This work generated a short list of six genes and their associated sites that should be given the highest priority for experimental validation in the laboratory in an effort to demonstrate a direct, repressive role for STAT5 in diabetic nephropathy.
Lonnie Welch (Advisor)
Chang Liu (Committee Member)
Frank Drews (Committee Member)
Karen Coschigano (Committee Member)
167 p.
Bioinformatics; Computer Science
STAT5; diabetic nephropathy; diabetes; inflammation; motif finding; TFBS

Recommended Citations

Citations

  • Schmidt, J. (2013). Discovery of Putative STAT5 Transcription Factor Binding Sites in Mice with Diabetic Nephropathy [Master's thesis, Ohio University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=ohiou1385482459

    APA Style (7th edition)

  • Schmidt, Jens. Discovery of Putative STAT5 Transcription Factor Binding Sites in Mice with Diabetic Nephropathy. 2013. Ohio University, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=ohiou1385482459.

    MLA Style (8th edition)

  • Schmidt, Jens. "Discovery of Putative STAT5 Transcription Factor Binding Sites in Mice with Diabetic Nephropathy." Master's thesis, Ohio University, 2013. http://rave.ohiolink.edu/etdc/view?acc_num=ohiou1385482459

    Chicago Manual of Style (17th edition)

ohiou1385482459
701
© 2013, all rights reserved.
This open access ETD is published by Ohio University and OhioLINK.