Skip to Main Content
 

Global Search Box

 
 
 

ETD Abstract Container

Abstract Header

Growth Hormone (GH) and the Cardiovascular System: Studies in Bovine GH Transgenic and Inducible, Cardiac-Specific GH Receptor Gene Disrupted Mice

Jara, Adam
http://rave.ohiolink.edu/etdc/view?acc_num=ohiou1395792687

Abstract Details

2014, Doctor of Philosophy (PhD), Ohio University, Biological Sciences (Arts and Sciences).
Growth hormone (GH) and insulin-like growth factor I (IGF-I) are thought to play key roles in the development and maintenance of the heart. Evidence of the profound effect GH has on the heart can be found in patients with diseases that disrupt GH action. In pathological states of acromegaly (caused by oversecretion of GH), GH deficiency, and Laron Syndrome (a disease caused by mutations in the GH receptor resulting in systemic lack of GH induced action), patients exhibit unique cardiovascular phenotypes of altered structure and function. Despite these observations, the exact role of GH in the cardiovascular system is not well characterized. To better understand the effects that GH action has on the cardiovascular system, we studied the well-established bovine GH (bGH) transgenic mouse and developed a novel tamoxifen-inducible, cardiac-specific GH receptor (GHR) gene disrupted mouse (iC-GHRKO). We find that the bGH mice exhibit an age-dependent elevation of systolic blood pressure that is correlated with changes in both the brain natriuretic peptide and renin angiotensin systems. Our initial characterization of the iC-GHRKO mice surprisingly reveals that cardiac GH signaling is not necessary for maintenance of baseline cardiac function, but does appear to be required for normal glucose homeostasis in older mice. These studies take us a step closer to understanding the role of GH in the cardiovascular system and imply complex hormonal regulation of both cardiovascular function and whole body metabolism.
John Kopchick (Advisor)
Darlene Berryman (Committee Member)
Shigeru Okada (Committee Member)
Calvin James (Committee Member)
213 p.
Endocrinology; Molecular Biology
growth hormone; GH; bovine growth hormone; bGH; cardiovascular; heart; growth hormone receptor; GHR; GHRKO

Recommended Citations

Citations

  • Jara, A. (2014). Growth Hormone (GH) and the Cardiovascular System: Studies in Bovine GH Transgenic and Inducible, Cardiac-Specific GH Receptor Gene Disrupted Mice [Doctoral dissertation, Ohio University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=ohiou1395792687

    APA Style (7th edition)

  • Jara, Adam. Growth Hormone (GH) and the Cardiovascular System: Studies in Bovine GH Transgenic and Inducible, Cardiac-Specific GH Receptor Gene Disrupted Mice . 2014. Ohio University, Doctoral dissertation. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=ohiou1395792687.

    MLA Style (8th edition)

  • Jara, Adam. "Growth Hormone (GH) and the Cardiovascular System: Studies in Bovine GH Transgenic and Inducible, Cardiac-Specific GH Receptor Gene Disrupted Mice ." Doctoral dissertation, Ohio University, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=ohiou1395792687

    Chicago Manual of Style (17th edition)

ohiou1395792687
1,250
© 2014, all rights reserved.
This open access ETD is published by Ohio University and OhioLINK.