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Investigation of Desulfovibrio vulgaris Biocorrosion Mechanism and Its Mitigation Using an Antimicrobial Enhanced by a D-amino Acid

Zhang, Peiyu
http://rave.ohiolink.edu/etdc/view?acc_num=ohiou1398770773

Abstract Details

2014, Master of Science (MS), Ohio University, Biomedical Engineering (Engineering and Technology).
Biocorrosion, also known as microbiologically influenced corrosion (MIC), which is primarily caused by microbial respiration or metabolic products of microbes, has been a major factor in the initiation and acceleration of metal corrosion. Apart from the destruction of pipelines and economic losses, MIC is also suspected to cause the failure of human implants. Metabolites such as hydrogen sulfide are a threat to human health. Sulfate reducing bacteria (SRB) often contribute to the MIC of pipelines and implants due to their wide distribution in industrial fields and in the human body. The biocatalytic cathodic sulfate reduction (BCSR) theory was proposed by Gu et al. (2009) to clarify the mechanism of MIC pitting corrosion caused by SRB. Extracellular electron transfer is the key step to explain how SRB MIC pitting happens. Riboflavin and flavin adenine dinucleotide (FAD), two common electron mediators used by many microbes, were found in lab tests to accelerate the electron transfer from metal surface to sessile cells, providing support to the BCSR theory. Starvation test using 304 and 316 stainless steel coupons suggested that SRB can utilize elemental iron as an electron donor when there is a local shortage of organic carbon underneath the SRB biofilm. A mixture of D-amino acids and THPS has been proposed to mitigate. D-amino acids are biocide enhancers that disperse sessile cells in biofilms under an antimicrobial stress. In order to achieve a better mitigation of implant MIC in the human body, a synergetic combination of a D-amino acid and an antibiotic was investigated. Decreased weight loss and MIC pit depth were obtained using a cocktail treatment of D-methionine and metronidazole.
Tingyue Gu (Advisor)
Monica Burdick (Committee Member)
Peter Coschigano (Committee Member)
Douglas Goetz (Committee Chair)
136 p.
Biomedical Engineering
MIC; SRB; Biofilm; Bioenergetics; Electron transfer; Mitigation

Recommended Citations

Citations

  • Zhang, P. (2014). Investigation of Desulfovibrio vulgaris Biocorrosion Mechanism and Its Mitigation Using an Antimicrobial Enhanced by a D-amino Acid [Master's thesis, Ohio University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=ohiou1398770773

    APA Style (7th edition)

  • Zhang, Peiyu. Investigation of Desulfovibrio vulgaris Biocorrosion Mechanism and Its Mitigation Using an Antimicrobial Enhanced by a D-amino Acid. 2014. Ohio University, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=ohiou1398770773.

    MLA Style (8th edition)

  • Zhang, Peiyu. "Investigation of Desulfovibrio vulgaris Biocorrosion Mechanism and Its Mitigation Using an Antimicrobial Enhanced by a D-amino Acid." Master's thesis, Ohio University, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=ohiou1398770773

    Chicago Manual of Style (17th edition)

ohiou1398770773
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© 2014, all rights reserved.
This open access ETD is published by Ohio University and OhioLINK.