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The Pivotal Role of Nitric Oxide and Peroxynitrite Imbalance in Epileptic Seizures

Jiang, Lu-Lin
http://rave.ohiolink.edu/etdc/view?acc_num=ohiou1407723694

Abstract Details

2014, Doctor of Philosophy (PhD), Ohio University, Chemistry and Biochemistry (Arts and Sciences).
Epilepsy is one of the most severe neurological disorders. However, the detailed molecular mechanism in triggering epileptic seizures is still unclear. Nitric oxide (NO) is a versatile neurotransmitter in the brain; it acts as a messenger and antiplatelet aggregation agent in the cerebral vasculature. Peroxynitrite (ONOO-), a cytotoxic compound, can be easily produced by the diffusion-controlled reaction between NO and superoxide anion (O2·-). This study used a nanomedical approach to elucidate the role of NO and ONOO- in epileptic seizures. The nanomedical approach involving a system of nanosensors (diameter 200~300nm) has been used to measure directly in vivo release of NO and ONOO- in the brains of Sprague-Dawley (SD) rats during the process of pilocarpine-induced epileptic seizure events. Seizure events were simultaneously monitored by electroencephalography (EEG). Pilocarpine stimulated both NO and ONOO- production in the brain. The ratio of NO to ONOO- concentration ([NO]/ [ONOO-]) that reflected the balance between NO and ONOO- shifted with time. Epileptic seizures were observed only at the relatively low ratio of [NO]/ [ONOO-]. The latency, duration, and frequency of seizure events have also been influenced by the balance between NO and ONOO-.
Tadeusz Malinski (Advisor)
153 p.
Biochemistry
Epileptic Seizure, Nitric Oxide, Peroxynitrite

Recommended Citations

Citations

  • Jiang, L.-L. (2014). The Pivotal Role of Nitric Oxide and Peroxynitrite Imbalance in Epileptic Seizures [Doctoral dissertation, Ohio University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=ohiou1407723694

    APA Style (7th edition)

  • Jiang, Lu-Lin. The Pivotal Role of Nitric Oxide and Peroxynitrite Imbalance in Epileptic Seizures. 2014. Ohio University, Doctoral dissertation. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=ohiou1407723694.

    MLA Style (8th edition)

  • Jiang, Lu-Lin. "The Pivotal Role of Nitric Oxide and Peroxynitrite Imbalance in Epileptic Seizures." Doctoral dissertation, Ohio University, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=ohiou1407723694

    Chicago Manual of Style (17th edition)

ohiou1407723694
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© 2014, all rights reserved.
This open access ETD is published by Ohio University and OhioLINK.