Skip to Main Content
Frequently Asked Questions
Submit an ETD
Global Search Box
Need Help?
Keyword Search
Participating Institutions
Advanced Search
School Logo
Files
File List
Zheng, Zilong Accepted Dissertation 8-8-16 Su16.pdf (2.19 MB)
ETD Abstract Container
Abstract Header
Synthesis of Oxazolidinone Derivatives and Anti-Influenza Agents
Author Info
Zheng, Zilong
Permalink:
http://rave.ohiolink.edu/etdc/view?acc_num=ohiou1470739369
Abstract Details
Year and Degree
2016, Doctor of Philosophy (PhD), Ohio University, Chemistry and Biochemistry (Arts and Sciences).
Abstract
Oxazolidinones Derivatives are useful compounds in both synthetic chemistry and biochemistry. The addition reaction of fused ring aziridine and halides was developed, which provide a new way of preparing of oxazolidinone derivatives. Here the halides could be both highly reactive haloformates and less reactive haloacetates, benzyl halides and allylic halides. The addition reaction of fused ring aziridine and iodoacetate also provided a way to the synthesis of bicyclic compound, which could be opened by amine and amino acid. The method proved to be a useful method in the synthesis of peptidomimetics with oxazolidinone structure. A library of A3 analogue were prepared as anti-influenza agents. Compared to A3 compound, the oxadiazole unit was replaced with different substitutions, such as hydrazide and triazole. The indole unit was replaced with benzyl group with different substitutions.
Committee
Stephen Bergmeier (Advisor)
Eric Masson (Committee Member)
Shiyong Wu (Committee Member)
Xiaozhuo Chen (Committee Member)
Pages
199 p.
Subject Headings
Chemistry
Keywords
Oxazolidinones
;
aziridine
;
anti-influenza
Recommended Citations
Refworks
EndNote
RIS
Mendeley
Citations
Zheng, Z. (2016).
Synthesis of Oxazolidinone Derivatives and Anti-Influenza Agents
[Doctoral dissertation, Ohio University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=ohiou1470739369
APA Style (7th edition)
Zheng, Zilong.
Synthesis of Oxazolidinone Derivatives and Anti-Influenza Agents.
2016. Ohio University, Doctoral dissertation.
OhioLINK Electronic Theses and Dissertations Center
, http://rave.ohiolink.edu/etdc/view?acc_num=ohiou1470739369.
MLA Style (8th edition)
Zheng, Zilong. "Synthesis of Oxazolidinone Derivatives and Anti-Influenza Agents." Doctoral dissertation, Ohio University, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=ohiou1470739369
Chicago Manual of Style (17th edition)
Abstract Footer
Document number:
ohiou1470739369
Download Count:
613
Copyright Info
© 2016, all rights reserved.
This open access ETD is published by Ohio University and OhioLINK.