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Nitric Oxide and Peroxynitrite Imbalance Triggers Cortical Hyper-Excitability and Migraine Headaches

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2017, Doctor of Philosophy (PhD), Ohio University, Chemistry and Biochemistry (Arts and Sciences).
Migraine is a neurovascular disorder which exhibits as debilitating pain and other auxiliary symptoms. The headache is incapacitating enough to render the patient inactive and unable to carry on with their daily activities. Excitable neurons that are susceptible to noxious stimulus and ongoing activity in their circuit promotes the manifestation of pain. Current treatments only treat acute nociception and are non-functional when the disease progresses to chronic conditions. Assessing the underlying mechanism for the development of these headaches could contribute to designing better therapeutic interventions. We attempted to study the effects of nitro-oxidative stress on the pathophysiology of migraine with aura. Our nanosensors allowed us to detect the real-time changes in NO and ONOO- and provided a valuable tool in the analysis of these two species that are involved in a number of physiological and pathological processes. Concurrent EEG measurements were undertaken to decipher the changes in the neuronal activity. The computation of [NO]/[ONOO-] provided a quantitative value for nitro-oxidative stress while spectral analysis of EEG reflected the changes in the synaptic transmission. We found an inverse correlation between fast neuronal oscillations and [NO]/[ONOO-]. Together, they showed a relationship between nitro-oxidative stress and neuronal hyperexcitability where both NO and ONOO- influenced the spiking profile of neurons. Different analgesics showed changes in the [NO]/[ONOO-] and mediated.
Tadeusz Malinski, PhD (Advisor)
Michael Held, PhD (Committee Member)
Hao Chen, PhD (Committee Member)
Sergio Ulloa, PhD (Committee Member)
114 p.

Recommended Citations

Citations

  • Mahmud, F. J. (2017). Nitric Oxide and Peroxynitrite Imbalance Triggers Cortical Hyper-Excitability and Migraine Headaches [Doctoral dissertation, Ohio University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=ohiou1481716721296335

    APA Style (7th edition)

  • Mahmud, Farina. Nitric Oxide and Peroxynitrite Imbalance Triggers Cortical Hyper-Excitability and Migraine Headaches. 2017. Ohio University, Doctoral dissertation. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=ohiou1481716721296335.

    MLA Style (8th edition)

  • Mahmud, Farina. "Nitric Oxide and Peroxynitrite Imbalance Triggers Cortical Hyper-Excitability and Migraine Headaches." Doctoral dissertation, Ohio University, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=ohiou1481716721296335

    Chicago Manual of Style (17th edition)