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Adhesion of Rolling Cell to Deformable Substrates in Shear Flow

Moshaei, Mohammad Hossein
http://orcid.org/0000-0002-8327-7245
http://rave.ohiolink.edu/etdc/view?acc_num=ohiou153373230467728

Abstract Details

2018, Master of Science (MS), Ohio University, Mechanical Engineering (Engineering and Technology).
Cell rolling onto vascular endothelium under hydrodynamic blood flow is an important mechanism in many physiological and pathological processes, such as inflammatory response and tumor metastasis. The blood-borne cells are in direct contact with the most inner layer of endothelium formed by a highly compliant layer of endothelial cells. The effect of substrate stiffness on the adhesive dynamics of rolling cells is poorly understood. The goal of this thesis is to develop a modeling framework to understand the physics underlying the specific adhesion of a rolling cell to a soft bio-adhesive substrate subjected to a viscous shear flow. Of particular importance is to predict the effect of substrate stiffness on stable adhesion and rolling velocity of the cell. The developed models show a direct correlation between the state of adhesion and the substrate compliance. The results of this Thesis are anticipated to enhance our understanding of cellular arrest by endothelium and provide a quantitative basis to rational design of the nano-particles for vascular drug delivery.
Sarvestani Alireza (Advisor)
Farnoud Amir (Committee Member)
Tees David (Committee Member)
Cotton John (Committee Member)
131 p.
Biomechanics; Biomedical Engineering; Biomedical Research; Biophysics; Chemical Engineering; Materials Science; Mathematics; Mechanical Engineering; Mechanics; Molecular Biology; Molecular Physics; Physics
Adhesive Dynamics; soft substrate; leukocyte; Selectin; Stochastic; Deterministic; Stability; Phase Plane; Cell Adhesion; Cancer; Drug Delivery; Particle delivery; Shear Flow; Deformable surface; leukocyte; Blood Flow; Red Blood cell; White Blood Cell

Recommended Citations

Citations

  • Moshaei, M. H. (2018). Adhesion of Rolling Cell to Deformable Substrates in Shear Flow [Master's thesis, Ohio University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=ohiou153373230467728

    APA Style (7th edition)

  • Moshaei, Mohammad Hossein. Adhesion of Rolling Cell to Deformable Substrates in Shear Flow. 2018. Ohio University, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=ohiou153373230467728.

    MLA Style (8th edition)

  • Moshaei, Mohammad Hossein. "Adhesion of Rolling Cell to Deformable Substrates in Shear Flow." Master's thesis, Ohio University, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=ohiou153373230467728

    Chicago Manual of Style (17th edition)

ohiou153373230467728
386
© 2018, all rights reserved.
This open access ETD is published by Ohio University and OhioLINK.