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Harnessing the Recognition Properties of Cucurbit[n]urils in Dynamic Supramolecular Polymers

Raeisi, Mersad
http://rave.ohiolink.edu/etdc/view?acc_num=ohiou1565963566821693

Abstract Details

2019, Doctor of Philosophy (PhD), Ohio University, Chemistry and Biochemistry (Arts and Sciences).
Cucurbit[n]urils (CB[n]) are hollow pumpkin-shaped molecular containers that can act as molecular hosts in the presence of specific guest molecules in water, and consequently self-assemble into host-guest inclusion complexes. Their versatility and exceptional molecular recognition properties have prompted researchers to utilize them for a variety of purposes such as protein conjugation, drug delivery, pharmaceuticals, and supramolecular polymerization. Here, we show that the recognition properties of CB[8] can be harnessed to prepare water-soluble metallosupramolecular polymers, and indeed sequence-specific polymers can be obtained in the presence of negative and positive monomers in solution. In the course of this study, we found that CB[n] can inhibit ligand exchanges in metal-ligand complexes. We also demonstrate that ditopic organic guests can self-assemble into short oligomers in the presence of CB[8], and possibly be used in protein-targeting dynamic combinatorial libraries.
Eric Masson, Dr. (Advisor)
215 p.
Chemistry
Supramolecular polymer; Self-assembly; Self-sorting

Recommended Citations

Citations

  • Raeisi, M. (2019). Harnessing the Recognition Properties of Cucurbit[n]urils in Dynamic Supramolecular Polymers [Doctoral dissertation, Ohio University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=ohiou1565963566821693

    APA Style (7th edition)

  • Raeisi, Mersad. Harnessing the Recognition Properties of Cucurbit[n]urils in Dynamic Supramolecular Polymers. 2019. Ohio University, Doctoral dissertation. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=ohiou1565963566821693.

    MLA Style (8th edition)

  • Raeisi, Mersad. "Harnessing the Recognition Properties of Cucurbit[n]urils in Dynamic Supramolecular Polymers." Doctoral dissertation, Ohio University, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=ohiou1565963566821693

    Chicago Manual of Style (17th edition)

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This open access ETD is published by Ohio University and OhioLINK.