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osu1029356546.pdf (724.79 KB)
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REHABILITATIVE INFLUENCE OF THERAPEUTIC ULTRASOUND TREATMENT ON CELLULAR MARKERS OF SKELETAL MUSCLE REGENERATION FOLLOWING BLUNT CONTUSION INJURY
Author Info
Wilkin, Linda D
Permalink:
http://rave.ohiolink.edu/etdc/view?acc_num=osu1029356546
Abstract Details
Year and Degree
2002, Doctor of Philosophy, Ohio State University, Physical Activity and Educational Services.
Abstract
Following skeletal muscle contusion injury, therapeutic ultrasound is one of the most commonly used treatment modalities among athletic trainers and other sports medicine practitioners, and is generally recognized by clinicians to be one of the most effective rehabilitative treatments for soft tissue injuries resulting from participation in sport-related physical activities. Pulsed ultrasound is characterized by a non-thermal, mechanical stimulation and, over the course of several days, this environment purportedly hastens the regenerative skeletal muscle healing process. However, the structural outcomes underlying this potential effect are poorly delineated and not well understood. Our working hypothesis was that following a blunt contusion injury to the gastrocnemius (GTN) muscle, ultrasound treatment would facilitate the recovery of several biological markers observed during the skeletal muscle regenerative repair process. Eighty male Wistar rats (3-mo) were studied. Following anesthetic administration, each animal received a bilateral contusion injury to the GTN muscle. Ultrasound treatment (pulsed, 3.3 MHz, l W/cm2, 20% duty cycle) was subsequently initiated six hours post-contusion injury unilaterally on the right (R) GTN muscle and ultrasound treatment was continued once daily for 7 days. At sacrifice, the left (non-ultrasound treated) and right (ultrasound treated) GTN muscles of 10 animals per group were excised at 1 -, 3 -, 5 -, 7 -, 14 -, 21 -, 28 -, and 40 - days post-contusion injury, trimmed of excess fat and connective tissue, and flash frozen for subsequent tissue analyses. There were no differences in muscle mass, total protein concentration, or fiber cross-sectional area (CSAf) between the right, ultrasound treated GTN muscles and the left, non-ultrasound treated GTN muscles at any time point examined. When CSAf was normalized to muscle mass, there were also no differences at any time point examined. There were no differences in myonuclear number or fiber cross-sectional area per myonuclei between the right, ultrasound treated GTN muscles or the left, non-ultrasound treated GTN muscles at any time point. The hypotheses were not supported and the results suggest that therapeutic ultrasound treatment is not effective in hastening the regeneration of skeletal muscle following a contusion injury.
Committee
Steven Devor (Advisor)
Pages
60 p.
Keywords
skeletal muscle injury
;
fiber cross-sectional area
;
myonuclear density
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Citations
Wilkin, L. D. (2002).
REHABILITATIVE INFLUENCE OF THERAPEUTIC ULTRASOUND TREATMENT ON CELLULAR MARKERS OF SKELETAL MUSCLE REGENERATION FOLLOWING BLUNT CONTUSION INJURY
[Doctoral dissertation, Ohio State University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=osu1029356546
APA Style (7th edition)
Wilkin, Linda.
REHABILITATIVE INFLUENCE OF THERAPEUTIC ULTRASOUND TREATMENT ON CELLULAR MARKERS OF SKELETAL MUSCLE REGENERATION FOLLOWING BLUNT CONTUSION INJURY.
2002. Ohio State University, Doctoral dissertation.
OhioLINK Electronic Theses and Dissertations Center
, http://rave.ohiolink.edu/etdc/view?acc_num=osu1029356546.
MLA Style (8th edition)
Wilkin, Linda. "REHABILITATIVE INFLUENCE OF THERAPEUTIC ULTRASOUND TREATMENT ON CELLULAR MARKERS OF SKELETAL MUSCLE REGENERATION FOLLOWING BLUNT CONTUSION INJURY." Doctoral dissertation, Ohio State University, 2002. http://rave.ohiolink.edu/etdc/view?acc_num=osu1029356546
Chicago Manual of Style (17th edition)
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Document number:
osu1029356546
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© 2002, all rights reserved.
This open access ETD is published by The Ohio State University and OhioLINK.