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osu1039034888.pdf (499.45 KB)
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MAXIMAL LACTATE STEADY STATE: INFLUENCE OF THE AGE-RELATED ADAPTATIONS OF SKELETAL MUSCLE
Author Info
Mattern, Craig O
Permalink:
http://rave.ohiolink.edu/etdc/view?acc_num=osu1039034888
Abstract Details
Year and Degree
2002, Doctor of Philosophy, Ohio State University, Physical Activity and Educational Services.
Abstract
Increased participation of aged individuals in competitive athletics warrants basic research focused on delineating age-related changes in performance variables. PURPOSE: Based on potential age-related declines in aerobic enzyme activities and a shift in the expression of myosin heavy chain (MHC) isoforms, we hypothesized that maximal lactate steady state (MLSS) exercise intensity would be altered as a function of age. METHODS: Three age groups [(YA, n=10, 25.1±0.9 years, 8.3±1.0 % fat) (MA, n=10, 42.9±1.0 years, 13.6±1.9 % fat) (OA, n=10, 63.9±2.5 years, 16.4±1.4 % fat)] of male, competitive cyclists and triathletes matched for training intensity and duration were studied. Subjects performed a VO2max test followed by a series of 30 min exercise trials to determine MLSS. The intensity of the first trial was 60% of maximal power output measured during the VO2max test. Workload of each subsequent trial was increased by 5% until blood lactate increased by > 1 mMol/L in the last 20 min of the 30 min trial. A muscle biopsy of the vastus lateralis was procured on a separate visit. RESULTS: There were significant (p<0.05) differences in VO2max between all age groups (YA = 66.9±1.4 ml•kg-1•min-1, MA = 55.5±2.4 ml•kg-1•min-1, OA = 46.8±2.3 ml•kg-1•min-1). When expressed as a percentage of VO2max, there was also a significant (p<0.05) age-related decrease in the relative MLSS exercise intensity (YA = 82.2±1.7%, MA = 76.0±1.3%, OA = 70.1±1.4%). However, there were no significant age-related changes in citrate synthase (CS) activity or MHC isoform profile. CONCLUSION: The hypothesis is supported as there is an age-related decline in MLSS exercise intensity in athletes matched for training intensity and duration. Additionally, the rate of this decline is approximately 3.8% per decade. While CS activity is moderately related (r = 0.44, p = 0.008) to relative MLSS intensity, it does not explain the age-related decline in MLSS. The mechanism(s) responsible for the observed age-related decline in MLSS is unknown. Supported by The Gatorade Sports Science Institute.
Committee
Steven Devor (Advisor)
Keywords
lactate
;
aging
;
metabolism
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Citations
Mattern, C. O. (2002).
MAXIMAL LACTATE STEADY STATE: INFLUENCE OF THE AGE-RELATED ADAPTATIONS OF SKELETAL MUSCLE
[Doctoral dissertation, Ohio State University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=osu1039034888
APA Style (7th edition)
Mattern, Craig.
MAXIMAL LACTATE STEADY STATE: INFLUENCE OF THE AGE-RELATED ADAPTATIONS OF SKELETAL MUSCLE.
2002. Ohio State University, Doctoral dissertation.
OhioLINK Electronic Theses and Dissertations Center
, http://rave.ohiolink.edu/etdc/view?acc_num=osu1039034888.
MLA Style (8th edition)
Mattern, Craig. "MAXIMAL LACTATE STEADY STATE: INFLUENCE OF THE AGE-RELATED ADAPTATIONS OF SKELETAL MUSCLE." Doctoral dissertation, Ohio State University, 2002. http://rave.ohiolink.edu/etdc/view?acc_num=osu1039034888
Chicago Manual of Style (17th edition)
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osu1039034888
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© 2002, all rights reserved.
This open access ETD is published by The Ohio State University and OhioLINK.