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The study of pain with blood oxygen level dependant functional magnetic resonance imaging

Ibinson, James W
http://rave.ohiolink.edu/etdc/view?acc_num=osu1092705600

Abstract Details

2004, Doctor of Philosophy, Ohio State University, Biomedical Engineering.
Using blood oxygen level dependent functional magnetic resonance imaging (BOLD FMRI), the brain areas activated by pain were studied. These initial studies lead to interesting new findings in the body’s response to pain and to the refinement of one method used in FMRI analysis for correction of physiologic noise (signal fluctuations caused by the cyclic and non-cyclic changes in the cardiovascular and respiratory status of the body). These investigations will be summarized below. In the first study, evidence was provided suggesting that the multiple painful stimulations used in typical pain FMRI block designs causes attenuation over time of the BOLD signal within activated areas. The demonstrated BOLD attenuation seems unique to pain studies. One possible explanations is that changing hemodynamics caused by a physiologic response to pain alter the BOLD response. The next study began the investigation of this by monitoring the physiologic response to pain for eight subjects. It was found that respiratory rate and tidal volume increased, while heart rate, cardiac output, end-tidal carbon dioxide levels, and global cerebral blood flow all decreased. The cause of these changes appears to be a combination of short-lived sympathetic and long lasting parasympathetic nervous system activations. It is well established that changes in respiration and global cerebral blood flow can affect the BOLD response, leading to the final investigation of this dissertation. Heart rate, respiratory rate and depth, and end-tidal carbon dioxide levels were collected during a BOLD FMRI study of pain. A new technique for removing signal that covaries with the actual breathing values present during the collection of each image and with end-tidal carbon dioxide levels was introduced. This technique showed in increase in model fit of 85%, and the functional maps showed an average increase in the number of activated pixels of 6.53% over the eight subjects. Including the breathing and end-tidal carbon dioxide levels were also shown to account for the accommodation, suggesting that it may be due to the physiologic response of the body to pain.
Petra Schmalbrock (Advisor)
125 p.
Functional magnetic resonance imaging; Pain; Physiologic noise; General linear modeling; Electrical nerve stimulation; Autonomic nervous system; End tidal carbon dioxide; Respiration; Cardiovascular function

Recommended Citations

Citations

  • Ibinson, J. W. (2004). The study of pain with blood oxygen level dependant functional magnetic resonance imaging [Doctoral dissertation, Ohio State University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=osu1092705600

    APA Style (7th edition)

  • Ibinson, James. The study of pain with blood oxygen level dependant functional magnetic resonance imaging. 2004. Ohio State University, Doctoral dissertation. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=osu1092705600.

    MLA Style (8th edition)

  • Ibinson, James. "The study of pain with blood oxygen level dependant functional magnetic resonance imaging." Doctoral dissertation, Ohio State University, 2004. http://rave.ohiolink.edu/etdc/view?acc_num=osu1092705600

    Chicago Manual of Style (17th edition)

osu1092705600
935
© 2004, all rights reserved.
This open access ETD is published by The Ohio State University and OhioLINK.