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Novel approaches in imaging and image-guided therapy: microfabrication, quantitative diagnostic methods, and a model of lymphangiogenesis

Short, Robert Franklin
http://rave.ohiolink.edu/etdc/view?acc_num=osu1117553725

Abstract Details

2005, Doctor of Philosophy, Ohio State University, Biomedical Engineering.
The work presented herein describes the investigation in several key areas related to imaging and image-guided therapy. Each area is of interest for advancing the state of the art and development of new techniques in image-guided therapy. First, the rationale and approaches for microfabrication of microparticles is advanced. A technique for microfabrication of biodegradable mircorparticles of tailorable geometry and monodisperse size is described as well as efforts and the design of an experimental set-up to optimize production. The applications of such microparticles as drug delivery vehicles or as agents for embolization (or both as in chemoembolization) make them a promising technology in image-guided therapy. A second related focus of study is presented in the area of quantitative diagnostics. Combining imaging techniques and analysis algorithms can both identify and quantify disease states. Precise determination the extent of disease can be used to gage response to therapy, i.e. provide outcome measures to develop new therapies, including those advanced by image-guidance. A novel imaging method for identification of disease states of the major airways and lungs in pediatric populations is presented. Lastly, an animal model suitable for the testing of therapies directed against lymphatic malformations and lymphangiogenesis is presented. This method of site-specific induction of de novo lymphatic malformations (LMs) expressing specific growth factor receptors will allow investigations in the function and formation of lymphatic vessels. Macrocystic LMs observed in this model are shown to be large enough to target using current image-guided approaches (sclerotherapy) to optimize treatment capabilities. Microcystic LMs are also induced in this model, which might allow development of therapy against this variant. The LMs cysts have promise as bioreactors to test particle-based therapies directed against lymphatic endothelium. Each of the presented areas has bearing for future advancements in the field of image-guided therapy. An understanding of the research in these areas will allow for appreciation and perhaps development of future innovations in imaging and image-guided therapy.
Derek Hansford (Advisor)
218 p.
Image-guided therapy; nanotechnology; nanomedicine; microfabrication; drug delivery; microparticles; controlled ventilation; tracheomalacia; air trapping; quantitative diagnostics; lymphatic malformations; lymphangiomas; sclerotherapy; animal model

Recommended Citations

Citations

  • Short, R. F. (2005). Novel approaches in imaging and image-guided therapy: microfabrication, quantitative diagnostic methods, and a model of lymphangiogenesis [Doctoral dissertation, Ohio State University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=osu1117553725

    APA Style (7th edition)

  • Short, Robert. Novel approaches in imaging and image-guided therapy: microfabrication, quantitative diagnostic methods, and a model of lymphangiogenesis. 2005. Ohio State University, Doctoral dissertation. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=osu1117553725.

    MLA Style (8th edition)

  • Short, Robert. "Novel approaches in imaging and image-guided therapy: microfabrication, quantitative diagnostic methods, and a model of lymphangiogenesis." Doctoral dissertation, Ohio State University, 2005. http://rave.ohiolink.edu/etdc/view?acc_num=osu1117553725

    Chicago Manual of Style (17th edition)

osu1117553725
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© 2005, all rights reserved.
This open access ETD is published by The Ohio State University and OhioLINK.