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osu1117591862.pdf (9.5 MB)
ETD Abstract Container
Abstract Header
Carbon dioxide assisted polymer micro/nanofabrication
Author Info
Yang, Yong
Permalink:
http://rave.ohiolink.edu/etdc/view?acc_num=osu1117591862
Abstract Details
Year and Degree
2005, Doctor of Philosophy, Ohio State University, Chemical Engineering.
Abstract
Polymer-based biomedical devices with micro/nano-sized features have attracted a great deal of interest from industries and academia. The common polymer processing methods involve either organic solvents or temperatures above the glass transition temperature (T
g
), which is undesirable for biomedical applications. On the basis of different properties near polymer surfaces from those in the bulk, we introduce subcritical fluids (particularly carbon dioxide, CO
2
) into polymer processing at the micro/nanoscale to produce and assemble these devices at low temperatures. In this study, the atomic force microscopy (AFM)/nanoparticles approach has been applied to evaluate the effect of CO
2
on the T
g
gradient near the polymer surface. Meanwhile, neutron reflectivity is utilized to measure CO
2
–enhanced chain mobility at the polymer surfaces below the polymer bulk T
g
and to investigate the competition between CO
2
enhancement and substrate confinement on the chain mobility. With this information, we demonstrated the CO
2
-assisted bonding of polymeric structures at both micro and nano scales and established guidelines for this technique. In addition, nano-sized fillers were added to polymer substrates to improve the dimensional stability and reinforce the polymeric nanostructures by forming strong interactions between the nano-fillers and polymer chains. The research results were utilized to produce, assemble, and functionalize well-defined three-dimensional (3D) scaffolds for tissue engineering. A variety of polymer microfabrication techniques were developed to produce planar biodegradable polymeric scaffold skeletons with open structures. Then the CO
2
bonding technique was applied to assemble these skeletons to a 3D scaffold at a low temperature. These microfabricated scaffolds have a uniform and well-defined geometry and structure, which allows for the study of cell attachment, spreading, and proliferation in scaffolds in a controlled and logical manner. Our research initiates a new field of polymer processing and will be of great benefit to the advancement of polymer thin film and polymer micro/nanofabrication technologies. With the presence of CO
2
, fabrication and assembly of micro/nanodevices can be performed at a biologically benign temperature, which is suitable for biomedical applications.
Committee
L. Lee (Advisor)
Pages
245 p.
Keywords
low temperature polymer micro/nanofabrication
;
carbon dioxide
;
surface glass transition temperature
;
chain mobility
;
atomic force microscopy
;
neutron reflectivity
;
polymer nanocomposites
;
reinforcement of polymeric nanostructures
Recommended Citations
Refworks
EndNote
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Citations
Yang, Y. (2005).
Carbon dioxide assisted polymer micro/nanofabrication
[Doctoral dissertation, Ohio State University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=osu1117591862
APA Style (7th edition)
Yang, Yong.
Carbon dioxide assisted polymer micro/nanofabrication.
2005. Ohio State University, Doctoral dissertation.
OhioLINK Electronic Theses and Dissertations Center
, http://rave.ohiolink.edu/etdc/view?acc_num=osu1117591862.
MLA Style (8th edition)
Yang, Yong. "Carbon dioxide assisted polymer micro/nanofabrication." Doctoral dissertation, Ohio State University, 2005. http://rave.ohiolink.edu/etdc/view?acc_num=osu1117591862
Chicago Manual of Style (17th edition)
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Document number:
osu1117591862
Download Count:
3,042
Copyright Info
© 2005, all rights reserved.
This open access ETD is published by The Ohio State University and OhioLINK.