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osu1127235519.pdf (16.57 MB)
ETD Abstract Container
Abstract Header
Nucleus basalis cholinergic lesions and defense responses
Author Info
Knox, Dayan K
Permalink:
http://rave.ohiolink.edu/etdc/view?acc_num=osu1127235519
Abstract Details
Year and Degree
2005, Doctor of Philosophy, Ohio State University, Psychology.
Abstract
This thesis is primarily concerned with how nucleus basalis cholinergic neurons influence defense behavior that may model fear and anxiety. A brief historical perspective of neuroscientific approaches to studying aversive emotions and a review of studies documenting the effect of nucleus basalis cholinergic lesions on defense responses are initially provided. Results from the experiments conducted in this thesis suggest that selective cholinergic lesions in the nucleus basalis attenuate approach-avoidance conflict when approach for a consumable reward is involved as part of the conflict. The results from the experiments also suggest that cortical arousal and modulation of motivational systems may be mechanisms by which nucleus basalis cholinergic neurons influence approach-avoidance conflict that involves a consumable reward. Approach-avoidance conflict is believed to be a potent source of anxiety and as a result, nucleus basalis cholinergic neurons may mediate anxiety that emerges from an approach-avoidance conflict.
Committee
Gary Berntson (Advisor)
Pages
115 p.
Keywords
nucleus basalis
;
anxiety
;
conflict
;
fear
;
arousal
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Citations
Knox, D. K. (2005).
Nucleus basalis cholinergic lesions and defense responses
[Doctoral dissertation, Ohio State University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=osu1127235519
APA Style (7th edition)
Knox, Dayan.
Nucleus basalis cholinergic lesions and defense responses.
2005. Ohio State University, Doctoral dissertation.
OhioLINK Electronic Theses and Dissertations Center
, http://rave.ohiolink.edu/etdc/view?acc_num=osu1127235519.
MLA Style (8th edition)
Knox, Dayan. "Nucleus basalis cholinergic lesions and defense responses." Doctoral dissertation, Ohio State University, 2005. http://rave.ohiolink.edu/etdc/view?acc_num=osu1127235519
Chicago Manual of Style (17th edition)
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Document number:
osu1127235519
Download Count:
373
Copyright Info
© 2005, all rights reserved.
This open access ETD is published by The Ohio State University and OhioLINK.