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osu1155662110.pdf (5.67 MB)
ETD Abstract Container
Abstract Header
Effect of localized structural perturbations on dendrimer structure
Author Info
Gabriel, Christopher J
Permalink:
http://rave.ohiolink.edu/etdc/view?acc_num=osu1155662110
Abstract Details
Year and Degree
2006, Doctor of Philosophy, Ohio State University, Chemistry.
Abstract
The synthesis and conformational properties of folded dendrons based on a 2-methoxyisophthalamide (2-OMe-IPA) repeat unit are described. The hydrodynamic properties of dendrons preorganized via the syn-syn conformational preference of 2-methoxyisophthalamide are compared with 2,6-pyridinedicarboxamide (2,6-pydic) analogues. The effect of subtle differences in the nature of the conformational equilibria that exist within the 2-OMe-IPA and 2,6-pydic repeat units on the global structural properties of the corresponding dendrons was explored computationally and by 1H-DOSY NMR spectroscopy and time-resolved fluorescence anisotropy (TRFA) measurements. Whereas the syn-syn preference of the 2-OMe-IPA branched repeat unit is stabilized entirely by intramolecular hydrogen-bonding interactions, this preference in the 2,6-pydic system is a consequence of both intramolecular hydrogen-bonding and dipole minimization effects. This branching unit was used to study the effect of placing photoresponsive groups in the interior and throughout compact helical dendrons. Azobenzene was used as the photochemical trigger to induce global conformational changes of the dendritic architecture. 2D-NOESY NMR indicated a highly compact helical structure when the azobenzenes were in the more thermally stable trans-conformation. Photoisomerization of azobenzene from trans to cis, induced a structural change to the compact nature of the dendrons, as evidenced by an increase in the hydrodynamic volume. This change was followed by UV-vis spectroscopy and 1H DOSY NMR. The activation parameters and rate constants of the thermal back isomerization were found.
Committee
Jonathon Parquette (Advisor)
Pages
350 p.
Subject Headings
Chemistry, Organic
Keywords
Dendrimer
;
Azobenzene
;
Folding
;
Kinetics
;
Hydrodynamic Volume
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Citations
Gabriel, C. J. (2006).
Effect of localized structural perturbations on dendrimer structure
[Doctoral dissertation, Ohio State University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=osu1155662110
APA Style (7th edition)
Gabriel, Christopher.
Effect of localized structural perturbations on dendrimer structure.
2006. Ohio State University, Doctoral dissertation.
OhioLINK Electronic Theses and Dissertations Center
, http://rave.ohiolink.edu/etdc/view?acc_num=osu1155662110.
MLA Style (8th edition)
Gabriel, Christopher. "Effect of localized structural perturbations on dendrimer structure." Doctoral dissertation, Ohio State University, 2006. http://rave.ohiolink.edu/etdc/view?acc_num=osu1155662110
Chicago Manual of Style (17th edition)
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Document number:
osu1155662110
Download Count:
1,413
Copyright Info
© 2006, all rights reserved.
This open access ETD is published by The Ohio State University and OhioLINK.