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Aberrant DNA methylation in human non-small cell lung cancer

Brena, Romulo Martin
http://rave.ohiolink.edu/etdc/view?acc_num=osu1172083621

Abstract Details

2007, Doctor of Philosophy, Ohio State University, Molecular Genetics.
Lung cancer is the leading cause of cancer-related death worldwide. Given its impact on human health, extensive research is being conducted in an effort to reduce the global lung cancer death toll. Specifically, much interest has been placed on the development of biomarkers and the discovery of novel prognostic factors. Over the past 2 decades it has become evident that the cancer genome is not only affected by genetic abnormalities, such as mutations, deletions and chromosomal rearrangements, but also by epigenetic changes which, together, contribute to the deregulation of transcription profiles. Epigenetic changes are defined as heritable lesions to the DNA affecting gene expression without altering the primary DNA sequence. These lesions typically involve a genomewide reduction in 5-methylcytosine, increased DNA methylation in gene promoter sequences and substitutions in histone tail modifications. Epigenetic changes have been shown to interact with one another, resulting in genomic instability, silencing of tumor suppressor genes, activation of oncogenes and derepression of transposable elements. As opposed to the irreversible nature of genetic lesions, epigenetic lesions can be reversed. Because of their reversibility, epigenetic alterations have become an attractive target for new therapies, which has resulted in the development of new anticancer compounds, several of which are currently in clinical trials. The field of epigenetics has expanded considerably since its inception. Integrative research approaches aimed at elucidating the contribution of genetic and epigenetic alterations to the tumorigenic process are being undertaken worldwide, generating promising results. In hopes of furthering the body of knowledge currently afforded by the epigenetics field, the work presented in this thesis is focus primarily on unraveling the role of DNA methylation in the diagnosis, etiology and potential treatment of lung cancer.
Christoph Plass (Advisor)
Biology, Genetics
Lung Cancer; OLIG1; DNA methylation

Recommended Citations

Citations

  • Brena, R. M. (2007). Aberrant DNA methylation in human non-small cell lung cancer [Doctoral dissertation, Ohio State University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=osu1172083621

    APA Style (7th edition)

  • Brena, Romulo. Aberrant DNA methylation in human non-small cell lung cancer. 2007. Ohio State University, Doctoral dissertation. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=osu1172083621.

    MLA Style (8th edition)

  • Brena, Romulo. "Aberrant DNA methylation in human non-small cell lung cancer." Doctoral dissertation, Ohio State University, 2007. http://rave.ohiolink.edu/etdc/view?acc_num=osu1172083621

    Chicago Manual of Style (17th edition)

osu1172083621
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© 2007, all rights reserved.
This open access ETD is published by The Ohio State University and OhioLINK.