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Omega-3 fatty acids effect on wound healing

McDaniel, Jodi C.

Abstract Details

2007, Doctor of Philosophy, Ohio State University, Nursing.
Physiological events in the initial, essential inflammatory stage of wound healing influence subsequent overlapping stages. Proinflammatory cytokines coordinate molecular and cellular processes during the inflammatory stage. Polyunsaturated fatty acids alter proinflammatory cytokine production, but how this phenomenon influences wound healing is not clearly understood. We examined effects of marine-derived omega-3 eicosapentaenoic and docosahexaenoic polyunsaturated fatty acids on proinflammatory cytokines in wound serum and time to complete healing in healthy, human skin. This randomized, experimental study of two groups, (N=30), compared plasma fatty acid levels at baseline and after four weeks of omega-3 supplements or placebo. Eight small blisters were created on all participants. Proinflammatory cytokines IL-1beta, IL-6, and TNF-alpha were measured in blister fluid at 5 and 24 hours after creation. Wound area was calculated daily until 100% closure. We found that eicosapentaenoic and docosahexaenoic plasma fatty acid levels were significantly greater in participants who received the supplement for 4 weeks than the control group. Additionally, there were significantly higher levels of IL-1beta in blister fluid in participants consuming the supplements and time to complete wound closure was no significantly longer. These results suggest that omega-3 eicosapentaenoic and docosahexaenoic polyunsaturated fatty acids increase proinflammatory cytokine production at wound sites and thus, depending on the clinical context, have noninvasive, therapeutic potential to affect skin wound healing .
Karen Ahijevych (Advisor)
85 p.

Recommended Citations

Citations

  • McDaniel, J. C. (2007). Omega-3 fatty acids effect on wound healing [Doctoral dissertation, Ohio State University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=osu1186629013

    APA Style (7th edition)

  • McDaniel, Jodi. Omega-3 fatty acids effect on wound healing. 2007. Ohio State University, Doctoral dissertation. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=osu1186629013.

    MLA Style (8th edition)

  • McDaniel, Jodi. "Omega-3 fatty acids effect on wound healing." Doctoral dissertation, Ohio State University, 2007. http://rave.ohiolink.edu/etdc/view?acc_num=osu1186629013

    Chicago Manual of Style (17th edition)