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The Partial Tandem Duplication of the MLL (MLL PTD)in Leukemogenesis

Dorrance, Adrienne M.
http://rave.ohiolink.edu/etdc/view?acc_num=osu1203712889

Abstract Details

2008, Doctor of Philosophy, Ohio State University, Veterinary Biosciences.
Although many advances have been made in the treatment of cancer in recent years, there is still a lot more to discover in the hopes of generating better therapies. Understanding how recurring genetic mutations are contributing to disease allows us to potentially uncover new pathways to target with newly synthesized or even previously developed drug therapies. My work focuses on a mutation known as the partial tandem duplication of the MLL (Mixed-Lineage Leukemia) gene, that is found in ~4-11% of acute myeloid leukemia (AML) patients with no other apparent genomic disruptions, i.e. normal cytogenetics. Patients with the MLL PTD have an especially poor prognosis, and therefore, identifying novel therapies for this particular subgroup is especially important. In order to identify the downstream targets of the MLL PTD, we created a mouse model of the MLL PTD. This model provides us with a powerful genetic tool to identify disruptions in normal cell processes as a result of the PTD, as well as a model to test potential therapies.
Michael Caligiuri (Advisor)
Laura Rush (Committee Member)
Denis Guttridge (Committee Member)
Danilo Perrotti (Committee Member)
106 p.
Molecular Biology
leukemia; MLL; Hox

Recommended Citations

Citations

  • Dorrance, A. M. (2008). The Partial Tandem Duplication of the MLL (MLL PTD)in Leukemogenesis [Doctoral dissertation, Ohio State University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=osu1203712889

    APA Style (7th edition)

  • Dorrance, Adrienne. The Partial Tandem Duplication of the MLL (MLL PTD)in Leukemogenesis. 2008. Ohio State University, Doctoral dissertation. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=osu1203712889.

    MLA Style (8th edition)

  • Dorrance, Adrienne. "The Partial Tandem Duplication of the MLL (MLL PTD)in Leukemogenesis." Doctoral dissertation, Ohio State University, 2008. http://rave.ohiolink.edu/etdc/view?acc_num=osu1203712889

    Chicago Manual of Style (17th edition)

osu1203712889
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© 2008, all rights reserved.
This open access ETD is published by The Ohio State University and OhioLINK.