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Development of novel implantable sensors for biomedical oximetry

Meenakshisundaram, Guruguhan
http://rave.ohiolink.edu/etdc/view?acc_num=osu1217427728

Abstract Details

2008, Doctor of Philosophy, Ohio State University, Biomedical Engineering.
This dissertation reports the development of novel implantable oxygen sensors made by the encapsulation of particulate electron paramagnetic resonance (EPR) oximetry probes in a biocompatible polymer matrix. Implants were fabricated by cast molding and polymerization, and exhibited a stable and linear oxygen calibration. In vitro testing of these polymeric biomaterials established their robustness and biostability. In addition, when cultured with cells (in the medium), the implants exhibited excellent in vitro biocompatibility and biodurability. In vivo testing of the long-term oxygen sensing performance showed stable, real-time response for up to 70 days. Functional validation using clinically relevant animal models of disease revealed that the implants were capable of accurately reporting the oxygenation of the tissue under study. The development of implantable oxygen sensors, presented in this dissertation, will enable the widespread application of EPR for in vivo oximetry and the successful clinical transformation of this promising research technique.
Stephen Lee (Advisor)
Periannan Kuppusamy (Committee Member)
Mark Ruegsegger (Committee Member)
199 p.
Biomedical Research
electron paramagnetic resonance; oximetry; particulate probes; implantable sensors; oxygen sensors; polymer; biocompatible; biomedical oximetry

Recommended Citations

Citations

  • Meenakshisundaram, G. (2008). Development of novel implantable sensors for biomedical oximetry [Doctoral dissertation, Ohio State University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=osu1217427728

    APA Style (7th edition)

  • Meenakshisundaram, Guruguhan. Development of novel implantable sensors for biomedical oximetry. 2008. Ohio State University, Doctoral dissertation. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=osu1217427728.

    MLA Style (8th edition)

  • Meenakshisundaram, Guruguhan. "Development of novel implantable sensors for biomedical oximetry." Doctoral dissertation, Ohio State University, 2008. http://rave.ohiolink.edu/etdc/view?acc_num=osu1217427728

    Chicago Manual of Style (17th edition)

osu1217427728
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© 2008, all rights reserved.
This open access ETD is published by The Ohio State University and OhioLINK.