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Characterization and Hydration with the SL-OCT

Morin, Craig E.

Abstract Details

2008, Master of Science, Ohio State University, Biomedical Engineering.

It is clinically relevant to develop a method to measure hydration in corneas because it is key to the maintenance of a clear cornea. The two studies presented here are aimed at characterizing the Heidelberg Engineering Slit-lamp Mounted Optical Coherence Tomographer (SL-OCT), observing the effect of hydration on the pachymetry and reflectivity of the normal and post-LASIK cornea, and evaluating the reflectivity measurement as an indicator of hydration level.

Eleven normal subjects were enrolled in the study to characterize the repeatability, intersession reproducibility, and interoperator reproducibility of the SL-OCT. A unitless reflectivity parameter, Reflectivity to Background Ratio (RBR), was defined as an indicator of corneal reflectivity. The pachymetry repeatability and reproducibility were found to be worse than with the Orbscan, Pentacam, and ultrasound pachymetry. Plots of the sample size requirements for various statistically significant differences were presented.

Eighteen subjects (36 eyes) were enrolled in the second study, of which 7 were post-LASIK. Corneal swelling was induced for 2 hours by exposure to a low-oxygen environment. Pachymetry and reflectivity data were collected pre-swelling, post-swelling and 150 minutes post-swelling. The significant differences found in pachymetry and RBR response to swelling between normal and LASIK corneas are likely the result of the altered structure imposed by the surgical procedure. A significant relationship was found between RBR and pachymetry for post-LASIK corneas in the peripheral regions but no overall relationship was found.

Deborah M. Grzybowski (Advisor)
Cynthia J. Roberts (Committee Member)
63 p.

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Citations

  • Morin, C. E. (2008). Characterization and Hydration with the SL-OCT [Master's thesis, Ohio State University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=osu1218601774

    APA Style (7th edition)

  • Morin, Craig. Characterization and Hydration with the SL-OCT. 2008. Ohio State University, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=osu1218601774.

    MLA Style (8th edition)

  • Morin, Craig. "Characterization and Hydration with the SL-OCT." Master's thesis, Ohio State University, 2008. http://rave.ohiolink.edu/etdc/view?acc_num=osu1218601774

    Chicago Manual of Style (17th edition)