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Social And Temporal Determinants Of Brain, Behavior And Immune Function

Weil, Zachary M.
http://rave.ohiolink.edu/etdc/view?acc_num=osu1219085420

Abstract Details

2008, Doctor of Philosophy, Ohio State University, Neuroscience.
In this dissertation, I will consider the consequences (physiological, behavioral, and susceptibility to injury) associated with adaptations to both changing biological times and alterations in the social environment. To that end This dissertation is divided into three sections. Section I (chapters 2 and 3) describe a series of experiments that investigate how the social environment regulates inflammatory and behavioral responses to acute administration. Those experiments were designed to determine how animals parse competing behavioral and physiological priorities in order to maximize fitness and survive infection. Section II (chapters 4 and 5) describe the first photoperiodism experiments in this dissertation (see below). Briefly, photoperiodism is the use of day length to regulate seasonal changes in physiology and behavior. Cell-mediated immune responses are typically enhanced in short winter-like day lengths. These experiments were designed to address the role of photoperiod exposure early in life and also the modulatory effects of social housing on photoperiod-mediated changes in the immune system. Section III (chapters 6-9) includes four experiments that investigated temporal and social factors that regulate functional outcomes following cardiac arrest and cardiopulmonary resuscitation. This final set of experiments was conducted to describe and investigate natural fluctuations in ischemic outcomes. I investigated ischemic outcomes at different times of day (chapter 6), after differential social housing (chapter 7), and after sleep deprivation (chapter 8). All of these experiments focused on the role of social and temporal variables in the regulation of inflammatory responses to ischemia.
Randy Nelson (Advisor)
Courtney A Devries (Committee Member)
Gary Berntson (Committee Member)
Georgia Bishop (Committee Member)
Courtney Lynch (Committee Member)
259 p.
Biomedical Research
neuroscience; neuroendocrinology; inflammation; cardiac arrest; seasonality; circadian rhythms; photoperiodism; sickness behaviors.

Recommended Citations

Citations

  • Weil, Z. M. (2008). Social And Temporal Determinants Of Brain, Behavior And Immune Function [Doctoral dissertation, Ohio State University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=osu1219085420

    APA Style (7th edition)

  • Weil, Zachary. Social And Temporal Determinants Of Brain, Behavior And Immune Function. 2008. Ohio State University, Doctoral dissertation. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=osu1219085420.

    MLA Style (8th edition)

  • Weil, Zachary. "Social And Temporal Determinants Of Brain, Behavior And Immune Function." Doctoral dissertation, Ohio State University, 2008. http://rave.ohiolink.edu/etdc/view?acc_num=osu1219085420

    Chicago Manual of Style (17th edition)

osu1219085420
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© 2008, all rights reserved.
This open access ETD is published by The Ohio State University and OhioLINK.