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MRI-Based Attenuation Correction for PET Reconstruction

Steinberg, Jeffrey

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2008, Doctor of Philosophy, Ohio State University, Physics.
In this study we proposed and developed a simple attenuation mapping approachbased on magnetic resonance imaging (MRI) for the purpose of reconstructing positron emission tomography (PET) images in PET/MRI imaging devices. After experimental development, an in vivo calibration was performed by whole body scanning of five beagles on both a PET/CT and MRI. The attenuation was determined by using an automatic segmentation algorithm to segment regions of air, lung, soft tissue, and bone and assigning them values of 0.002 cm-1, 0.030 cm-1, 0.098 cm-1, and 0.130 cm-1 respectively. The CT attenuated PET images and the MRI attenuated PET images were very similar, and average standardized uptake values (SUV) for most regions of interest differed by 1% - 6%. Also, mean relative differences (MRD) between the images were between 5% and 9% for most regions. The only exception is bone, where the three region MRI attenuated PET images had an SUV 9% less on average than the CT attenuation images, and the MRD averaged 14%. Also, additional segmentation of bone in the four region MRI attenuated PET images reduced the SUV difference to 3% and the MRD to 6%. However, the differences between the CT and 3 region attenuations were much smaller than the differences between CT attenuated and unattenuated PET images, which had average SUVs of 1-37% and MRDs of 10-45%. In particular the spine had an average SUV difference of 29% and MRD of 45%. Therefore, despite the improvements in the four region segmentation, the three region segmentation without delineation of osseous tissues produces high quality images that are sufficient for most expected clinical purposes.
Klaus Honscheid (Advisor)
Michael Knopp (Advisor)
Richard Furnstahl (Committee Member)
Thomas Humanic (Committee Member)
97 p.

Recommended Citations

Citations

  • Steinberg, J. (2008). MRI-Based Attenuation Correction for PET Reconstruction [Doctoral dissertation, Ohio State University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=osu1219938403

    APA Style (7th edition)

  • Steinberg, Jeffrey. MRI-Based Attenuation Correction for PET Reconstruction. 2008. Ohio State University, Doctoral dissertation. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=osu1219938403.

    MLA Style (8th edition)

  • Steinberg, Jeffrey. "MRI-Based Attenuation Correction for PET Reconstruction." Doctoral dissertation, Ohio State University, 2008. http://rave.ohiolink.edu/etdc/view?acc_num=osu1219938403

    Chicago Manual of Style (17th edition)