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Use Of Chronic Lymphocytic Leukemia Research Consortium Data Repository And Gene Expression Omnibus To Generate And Test Hypotheses For Biomarker Identification And Development

KEEN, KRISTIN C.
http://rave.ohiolink.edu/etdc/view?acc_num=osu1230840233

Abstract Details

2009, Master of Science, Ohio State University, Pathology.
Chronic lymphocytic leukemia (CLL) is the most common adult leukemia in the United States. There is no known cure for CLL. While biomarkers have been found to correlate with disease progression, such as CD38, IGHV, and ZAP-70, there is a need for further validation of these biomarkers as well as new biomarker discovery. In this study, publicly available gene expression data from NCBI's Gene Expression Omnibus was used to identify genes with expression correlated to ZAP-70 and CD38 mRNA expression patterns. Also utilized were vast amounts of data from the Chronic Lymphocytic Leukemia Research Consortium (CRC) to search for novel correlations between clinical markers and disease progression and treatment outcome. We found several hundred genes with expression patterns correlated to ZAP-70. We also found several clinical, genetic, biologic, and immunologic CRC data fields which were correlated significantly and at weakly to strongly associated.
KUN HUANG, PhD (Advisor)
PHILIP PAYNE, PhD (Committee Member)
47 p.
Pathology
CHRONIC LYMPHOCYTIC LEUKEMIA; CORRELATION; CRC

Recommended Citations

Citations

  • KEEN, K. C. (2009). Use Of Chronic Lymphocytic Leukemia Research Consortium Data Repository And Gene Expression Omnibus To Generate And Test Hypotheses For Biomarker Identification And Development [Master's thesis, Ohio State University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=osu1230840233

    APA Style (7th edition)

  • KEEN, KRISTIN. Use Of Chronic Lymphocytic Leukemia Research Consortium Data Repository And Gene Expression Omnibus To Generate And Test Hypotheses For Biomarker Identification And Development. 2009. Ohio State University, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=osu1230840233.

    MLA Style (8th edition)

  • KEEN, KRISTIN. "Use Of Chronic Lymphocytic Leukemia Research Consortium Data Repository And Gene Expression Omnibus To Generate And Test Hypotheses For Biomarker Identification And Development." Master's thesis, Ohio State University, 2009. http://rave.ohiolink.edu/etdc/view?acc_num=osu1230840233

    Chicago Manual of Style (17th edition)

osu1230840233
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© 2009, all rights reserved.
This open access ETD is published by The Ohio State University and OhioLINK.