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Protective effects of Zinc-L-Carnosine/ Vitamin E on aspirin-induced gastroduodenal injury in dogs

Baan, Mieke
http://rave.ohiolink.edu/etdc/view?acc_num=osu1242760910

Abstract Details

2009, Master of Science, Ohio State University, Veterinary Clinical Sciences.
Zinc-L-carnosine has protective effects against epithelial injury in cell culture and rodent models of gastrointestinal (GI) mucosal injury. This randomized double-blinded placebo-controlled study investigated the protective effects of zinc-L-carnosine in combination with alpha-tocopheryl acetate (vitamin E) on the development of aspirin-induced GI lesions in dogs. Eighteen healthy mixed-breed dogs were given 1 tablet (n=6) or 2 tablets (n=6) of 30 mg zinc-L-carnosine/ 30 IU vitamin E q12h PO, or a placebo (n=6) on Days 0 – 35. On Days 7 – 35, all dogs were given 25 mg/kg buffered aspirin q8h PO. Endoscopy was performed on Days -1, 14, 21, and 35, and GI lesions were scored using a 12-point grading scale. All dogs developed mucosal lesions. Treatment had no significant effect on gastric (p=0.31) or duodenal lesion scores (p=0.067). Zinc-L-carnosine/ vitamin E did not prevent gastric mucosal lesions in an aspirin-induced model for GI injury.
Robert Sherding, Professor (Advisor)
Stephen DiBartola, Professor (Committee Member)
Susan Johnson, Associate Professor (Committee Member)
Veterinary Services
polaprezinc; zinc-L-carnosine; vitamin E; dog; gastroduodenal injury; endoscopy; aspirin

Recommended Citations

Citations

  • Baan, M. (2009). Protective effects of Zinc-L-Carnosine/ Vitamin E on aspirin-induced gastroduodenal injury in dogs [Master's thesis, Ohio State University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=osu1242760910

    APA Style (7th edition)

  • Baan, Mieke. Protective effects of Zinc-L-Carnosine/ Vitamin E on aspirin-induced gastroduodenal injury in dogs. 2009. Ohio State University, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=osu1242760910.

    MLA Style (8th edition)

  • Baan, Mieke. "Protective effects of Zinc-L-Carnosine/ Vitamin E on aspirin-induced gastroduodenal injury in dogs." Master's thesis, Ohio State University, 2009. http://rave.ohiolink.edu/etdc/view?acc_num=osu1242760910

    Chicago Manual of Style (17th edition)

osu1242760910
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© 2009, all rights reserved.
This open access ETD is published by The Ohio State University and OhioLINK.