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A Study of Contact Lens Comfort in Patients Wearing Comfilcon A Soft Contact Lenses Compared to Their Habitual Soft Contact Lenses

Hager, Michele LynnManeca
http://rave.ohiolink.edu/etdc/view?acc_num=osu1243711014

Abstract Details

2009, Master of Science, Ohio State University, Vision Science.
Contact lens discomfort, especially contact lens-related ocular dryness, is a major cause of contact lens wear discontinuation. Many studies have evaluated different contact lens materials for their comfort in both normal patients and sufferers of contact lens-related dry eye. This study seeks to evaluate a new silicone hydrogel soft contact lens material (comfilcon A) in terms of comfort, measurable tear film parameters, and total contact lens-extracted lipid in normal and contact lens-related dry eye contact lens wearers as compared to their habitual contact lenses. Thirty four participants completed this study consisting of two visits—the first with participant wearing their habitual soft contact lenses and the second with the study contact lenses. Interferometric measurements of the pre-lens tear film thinning rate (PLTF thinning rate), the lipid layer thickness (LLT), and the initial pre-lens tear film thickness (PLTF) were recorded, the Contact Lens Dry Eye Questionnaire (CLDEQ) was peformed, and the participants’ lenses were collected for lipid analysis at each visit. The CLDEQ scores at the first study visit of the non-dry eye and dry eye group were shown to be significantly different from one another (p <0.0001). Total extracted lipid amounts showed a significant difference for the non-dry eye group between the first and second study visits (p = 0.01) but not for the dry eye group (p = 0.10). A significant correlation was found between LLT and PLTF thinning rate for the first visit (r = 0.39, p = 0.03), but not for the second visit (r = 0.14, p = 0.43). A significant correlation was found between CLDEQ score and PLTF thinning rate for the dry eye group (rs = -0.55, p = 0.03) but not for the non-dry eye group (rs = 0.11, p = 0.71) at the first visit. A significant correlation was found between CLDEQ score and LLT for the non-dry eye group (rs = -0.53, p = 0.04) but not for the dry eye group (rs = -0.18, p = 0.53) at the first visit. A significant correlation was found between contact lens-extracted lipid quantity and number of days for which the habitual contact lenses were worn (r = 0.37, p = 0.03). One month of wear of comfilcon A silicone hydrogel contact lenses did not significantly improve subjective dryness symptom severity in either normals or contact lens-related dry eye sufferers as compared to their habitual lens materials. Further research is needed to determine a quantifiable tear film parameter or other marker by which to diagnose or grade contact lens-related dry eye and is also needed to find or develop a soft contact lens material that can be comfortably worn by contact lens-related dry eye sufferers.
Jason Nichols, OD, PhD, MPH (Advisor)
Kelly Nichols, OD, PhD, MPH (Committee Member)
P. Ewen King-Smith, PhD (Other)
83 p.
Ophthalmology
dry eye; comfilcon A; interferometry; lipid layer thickness; pre-lens tear film thinning rate; pre-lens tear film thickness; contact lens dry eye questionnaire

Recommended Citations

Citations

  • Hager, M. L. (2009). A Study of Contact Lens Comfort in Patients Wearing Comfilcon A Soft Contact Lenses Compared to Their Habitual Soft Contact Lenses [Master's thesis, Ohio State University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=osu1243711014

    APA Style (7th edition)

  • Hager, Michele. A Study of Contact Lens Comfort in Patients Wearing Comfilcon A Soft Contact Lenses Compared to Their Habitual Soft Contact Lenses. 2009. Ohio State University, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=osu1243711014.

    MLA Style (8th edition)

  • Hager, Michele. "A Study of Contact Lens Comfort in Patients Wearing Comfilcon A Soft Contact Lenses Compared to Their Habitual Soft Contact Lenses." Master's thesis, Ohio State University, 2009. http://rave.ohiolink.edu/etdc/view?acc_num=osu1243711014

    Chicago Manual of Style (17th edition)

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This open access ETD is published by The Ohio State University and OhioLINK.